Jouyban Handbook of Solubility Data for Pharmaceuticals

Erscheinungsjahr 2010
ISBN: 978-1-4398-0488-9
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: 0 - No protection

E-Book, Englisch, 552 Seiten

Aqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticals provides an extensive database of solubility for pharmaceuticals in mono solvents and binary solvents. Aqueous solubility data can be found in the Handbook of Aqueous Solubility Data by Samuel Yalkowsky and Yan He. Visit www.crcpress.com for more information.

In addition to the experimental efforts to measure the solubility of drugs in mono and mixed solvents, this book discusses the advantages and limitations of a number of mathematical models used to predict the solubility in mono or mixed solvent systems. It covers the pharmaceutical cosolvents and other organic solvents that are used in syntheses, separations, and other pharmaceutical processes. The solutes featured include the available data for official drugs, drug candidates, precursors of drugs, metabolites, and degradation products of pharmaceuticals. The author also presents the solubilities of amino acids since they play an important role in peptide drug properties.

Collecting drug solubilities in various cosolvents, this time-saving handbook includes the mixtures and model constants needed to predict undetermined solubilities. It describes mathematical models that enable data to be derived and provides estimates on how drugs are likely to behave in a given cosolvent. A software program and associated user manual are available on the author’s website.

Zielgruppe

Pharmaceutical and chemical researchers, medical and computational chemists, software designers, and advanced graduate students in pharmaceutical science or chemistry.

Autoren/Hrsg.

Jouyban, Abolghasem

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie

Inhaltsverzeichnis

Introduction
Solubility Determination Methods
Aqueous Solubility Prediction Methods
Solubility Prediction in Organic Solvents
The Accuracy Criteria in Solubility Calculation Methods
Acceptable MPD Range in Solubility Calculations
Solubilization of Drugs by Cosolvency
Review of Cosolvency Models
Concluding Remarks

Solubility Data in Organic Solvents

Solubility Data in Binary Solvent Mixtures

Solubility Data in Ternary Solvent Mixtures

Subject Index
Drug Index
Solvent Index
CAS Number
List of Abbreviations

References appear at the end of each chapter.

Über Autor(innen)

Abolghasem Jouyban is a professor of pharmaceutical analysis at Tabriz University of Medical Sciences in Iran.