Handbook of Solubility Data for Pharmaceuticals

1. Auflage 2009
ISBN: 978-1-4398-0485-8
Verlag: Taylor & Francis Inc

Buch, Englisch, 552 Seiten, Format (B × H): 178 mm x 254 mm, Gewicht: 1157 g

Aqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticals provides an extensive database of solubility for pharmaceuticals in mono solvents and binary solvents. Aqueous solubility data can be found in the Handbook of Aqueous Solubility Data by Samuel Yalkowsky and Yan He. Visit www.crcpress.com for more information.

In addition to the experimental efforts to measure the solubility of drugs in mono and mixed solvents, this book discusses the advantages and limitations of a number of mathematical models used to predict the solubility in mono or mixed solvent systems. It covers the pharmaceutical cosolvents and other organic solvents that are used in syntheses, separations, and other pharmaceutical processes. The solutes featured include the available data for official drugs, drug candidates, precursors of drugs, metabolites, and degradation products of pharmaceuticals. The author also presents the solubilities of amino acids since they play an important role in peptide drug properties.

Collecting drug solubilities in various cosolvents, this time-saving handbook includes the mixtures and model constants needed to predict undetermined solubilities. It describes mathematical models that enable data to be derived and provides estimates on how drugs are likely to behave in a given cosolvent. A software program and associated user manual are available on the author’s website.

Zielgruppe

Pharmaceutical and chemical researchers, medical and computational chemists, software designers, and advanced graduate students in pharmaceutical science or chemistry.

Autoren/Hrsg.

Jouyban, Abolghasem (Tabriz University, Iran)

Jouyban, Abolghasem

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Kosmetische Technologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie

Inhaltsverzeichnis

Introduction. Solubility Data in Organic Solvents. Solubility Data in Binary Solvent Mixtures. Solubility Data in Ternary Solvent Mixtures. Indices.

Über Autor(innen)

Abolghasem Jouyban is a professor of pharmaceutical analysis at Tabriz University of Medical Sciences in Iran.