Graca The Immune Synapse as a Novel Target for Therapy

1. Auflage 2007
ISBN: 978-3-7643-8296-4
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 192 Seiten

Reihe: Progress in Inflammation Research

This volume gives an overview on the progress in immune synapse research, from basic science to clinical trials, and the major mechanisms involved. It discusses how interfering with T cell activation may lead to immune tolerance, immune modulation, and the recruitment of regulatory T cells; the role of monoclonal antibodies in tolerance induction; and mechanisms maintaining dominant tolerance.

Autoren/Hrsg.

Graca, Luis

Inhaltsverzeichnis

1;Contents;6
2;List of contributors;8
3;Preface;11
4;The immune synapse and T cell activation: regulation by chemokines;13
5;The induction of regulatory T cells by targeting the immune synapse;26
6;Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology;46
7;Targeting CD4 for the induction of dominant tolerance;59
8;Anti-CD3: from T cell depletion to tolerance induction;67
9;Immune modulation by CD40L blockade;81
10;CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance;97
11;Adhesion molecules as therapeutic targets;117
12;E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?;139
13;FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells;157
14;Transforming growth factor-ß: From its effect in T cell activation to a role in dominant tolerance;165
15;From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic;179
16;Index;196