E-Book, Englisch, 192 Seiten, eBook
Graca The Immune Synapse as a Novel Target for Therapy
2008
ISBN: 978-3-7643-8296-4
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, 192 Seiten, eBook
Reihe: Progress in Inflammation Research
ISBN: 978-3-7643-8296-4
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark
This volume gives an overview on the progress in immune synapse research, from basic science to clinical trials, and the major mechanisms involved. It discusses how interfering with T cell activation may lead to immune tolerance, immune modulation, and the recruitment of regulatory T cells; the role of monoclonal antibodies in tolerance induction; and mechanisms maintaining dominant tolerance.
Zielgruppe
Professional/practitioner
Autoren/Hrsg.
Weitere Infos & Material
The immune synapse and T cell activation: regulation by chemokines.- The induction of regulatory T cells by targeting the immune synapse.- Infiltrating the immunological synapse: prospects for the use of altered petide ligands for the treatment of immune pathology.- Targeting CD4 for the induction of dominant tolerance.- Anti-CD3: from T cell depletion to tolerance induction.- Immune modulation by CD40L blockade.- CTLA-4-Ig and indoleamine 2,3-dioxygenase (IDO) in dominant tolerance.- Adhesion molecules as therapeutic targets.- E3 ubiquitin ligases and immune tolerance: targeting the immune synapse from within?.- FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells.- TGF-ß: from its effect in T cell activation to a role in dominant tolerance.- From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic.
