E-Book, Englisch, 119 Seiten, eBook
Chrubasik / Mather Postoperative Epidural Opioids
1993
ISBN: 978-3-642-78320-3
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, 119 Seiten, eBook
ISBN: 978-3-642-78320-3
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark
Epidural opioids are widely used in the management of post-
operative pain. On the basis of an extensive review of the
literature the authors here present their own interpretation
of current knowledge of how
the distribution and effectiveness of epidurally
administered
opiods are fundamentally determined.
They conclude that all opioids that are
currently being used to treat postoperative epidural pain
carry the potential risk of severe
side effects if the dose regimens are not tailored to the
patient`s individual analgesic need.
This book will serve to stimulate new ideas among pain
specialistst.
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
Epidural and Intrathecal Space.- Anatomy.- Puncture of the Meninges.- Distribution of Solutions.- Determinants of Opioid Activity.- Physicochemical Properties.- Distribution and Elimination.- Opioid Receptors.- Supraspinal Receptor Sites.- Spinal Receptor Sites.- Receptor Affinities.- Receptor Binding Kinetics.- Opioid Pharmacokinetics After Epidural Administration.- Transfer Across the Meninges.- Uptake into the CSF.- Distribution within the CSF.- Elimination from CSF.- Uptake into Spinal Cord and Brain.- Uptake into Epidural Fat.- Vascular Uptake into the Systemic Circulation.- Following Epidural Bolus Injections.- During Continuous Epidural Opioid Treatment.- Elimination from Blood.- Summary.- Clinical Implications.- Onset Time of Analgesia.- Duration of Action.- Injection Volume.- Addition of Epinephrine.- Side-Effects.- Pruritus.- Urinary Retention.- Early Respiratory Depression.- Late Respiratory Depression.- Treatment.- Quality of Analgesia.- Relative to Systemic Opioids.- Injection Volume.- Addition of Local Anesthetics.- The Optimum Dosage Regimen.- Summary.- Relative Analgesic Potencies.- Definition.- Quantitation from Postoperative Dose Requirements..- Interpretation.- Summary.- Risk-Benefit Evaluation.- Morphine.- Meperidine.- Methadone.- Alfentanil.- Fentanyl.- Sufentanil.- Buprenorphine.- Tramadol.- Summary.- References.
