Buch, Englisch, 119 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 219 g
ISBN: 978-3-540-56871-1
Verlag: Springer Berlin Heidelberg
Epidural opioids are widely used in the management of post-
operative pain. On the basis of an extensive review of the
literature the authors here present their own interpretation
of current knowledge of how
the distribution and effectiveness of epidurally
administered
opiods are fundamentally determined.
They conclude that all opioids that are
currently being used to treat postoperative epidural pain
carry the potential risk of severe
side effects if the dose regimens are not tailored to the
patient`s individual analgesic need.
This book will serve to stimulate new ideas among pain
specialistst.
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
Epidural and Intrathecal Space.- Anatomy.- Puncture of the Meninges.- Distribution of Solutions.- Determinants of Opioid Activity.- Physicochemical Properties.- Distribution and Elimination.- Opioid Receptors.- Opioid Pharmacokinetics After Epidural Administration.- Transfer Across the Meninges.- Uptake into the CSF.- Distribution within the CSF.- Elimination from CSF.- Uptake into Spinal Cord and Brain.- Uptake into Epidural Fat.- Vascular Uptake into the Systemic Circulation.- Elimination from Blood.- Summary.- Clinical Implications.- Onset Time of Analgesia.- Duration of Action.- Side-Effects.- Quality of Analgesia.- Summary.- Relative Analgesic Potencies.- Definition.- Quantitation from Postoperative Dose Requirements.- Interpretation.- Summary.- Risk-Benefit Evaluation.- Morphine.- Meperidine.- Methadone.- Alfentanil.- Fentanyl.- Sufentanil.- Buprenorphine.- Tramadol.- Summary.- References.
