Boehm / Takahama Thymic Development and Selection of T Lymphocytes

2014
ISBN: 978-3-642-40252-4
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 373, 132 Seiten, eBook

Reihe: Current Topics in Microbiology and Immunology

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

Zielgruppe

Research

Autoren/Hrsg.

Boehm, Thomas

Takahama, Yousuke

Inhaltsverzeichnis

Development and Function of Cortical Thymic Epithelial Cells.- Mechanisms of Thymus Medulla Development And Function.- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.-  Central Tolerance Induction.- Trafficking to the Thymus.- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.