Zhang / Xi / Chattopadhyaya Medicinal Chemistry of Nucleic Acids

1. Auflage 2011
ISBN: 978-1-118-09281-1
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 464 Seiten, E-Book

Reihe: Wiley series in drug discovery and development

Complete, up-to-date coverage of the broad area of nucleic acidchemistry and biology
Assembling contributions from a collection of authors withexpertise in all areas of nucleic acids, medicinal chemistry, andtherapeutic applications, Medicinal Chemistry of NucleicAcids presents a thorough overview of nucleic acidchemistry--a rapidly evolving and highly challengingdiscipline directly responsible for the development of antiviraland antitumor drugs. This reliable resource delves into a multitudeof subject areas involving the study of nucleic acids--such asthe new advances in genome sequencing, and the processes forcreating RNA interference (RNAi) based drugs--to assistpharmaceutical researchers in removing roadblocks that hinder theirability to predict drug efficacy. Offering the latest cutting-edgescience in this growing field, Medicinal Chemistry of Nucleic Acidsincludes:
* In-depth coverage of the development and application of modifiednucleosides and nucleotides in medicinal chemistry
* A close look at a large range of current topics on nucleic acidchemistry and biology
* Essential information on the use of nucleic acid drugs to treatdiseases like cancer
* A thorough exploration of siRNA for RNAi and the regulation ofmicroRNA, non-coding RNA (ncRNA), a newly developing and excitingresearch area
Thorough in its approach and promising in its message,Medicinal Chemistry of Nucleic Acids probes the new domainsof pharmaceutical research--and exposes readers to a wealth ofnew drug discovery opportunities emerging in the dynamic field ofnucleic acid chemistry.

Autoren/Hrsg.

Zhang, Li-He

Zhang, Lihe

Xi, Zhen

Chattopadhyaya, Jyoti

Weitere Mitwirkende

Hecht, Sidney M.

Inhaltsverzeichnis

FOREWORD vii
CONTRIBUTORS xi
INTRODUCTION xv
1 RECENT ADVANCES IN CARBOCYCLIC NUCLEOSIDES: SYNTHESIS ANDBIOLOGICAL ACTIVITY 1
Jianing Wang, Ravindra K. Rawal, and Chung K. Chu
2 STRUCTURES AND FUNCTIONS OF NUCLEIC ACIDS MODIFIED WITH S, Se,AND Te AND COMPLEXED WITH SMALL MOLECULES 101
Wen Zhang, Jia Sheng, and Zhen Huang
3 UNRAVELING OF THE NAD CYCLIZING AND CALCIUM SIGNALINGFUNCTIONS OF HUMAN CD38 142
Hon Cheung Lee
4 DNA AND RNA BINDING SMALL MOLECULES 164
Shibo Li and Zhen Xi
5 G-QUADRUPLEX DNA AND ITS LIGANDS IN ANTICANCER THERAPY206
Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, andLian-Quan Gu
6 MOLECULAR MODELING IN NUCLEIC ACID-TARGETED DRUG DESIGN258
Lidan Sun, Hongwei Jin, Liangren Zhang, and Lihe Zhang
7 STRUCTURE OF 10-23 DNAzyme IN COMPLEX WITH THE TARGETRNA IN SILICO--A PROGRESS REPORT ON THE MECHANISM OFRNA CLEAVAGE BY DNA ENZYME 272
Oleksandr Plashkevych and Jyoti Chattopadhyaya
8 LABELING OLIGONUCLEOTIDES TOWARD THE BIOMEDICAL PROBE292
Il Joon Lee and Byeang Hyean Kim
9 LOCKED NUCLEIC ACID OLIGONUCLEOTIDES TOWARD CLINICALAPPLICATIONS 335
Rakesh N. Veedu and Jesper Wengel
10 THE PHARMACOKINETICS RESEARCH OF NUCLEIC ACID DRUGS 349
Shengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao,Caihong Liu, and Ying Wang
11 INDUCIBLE RNAi AND DRUG TARGET VALIDATION 390
Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng,Qiu-Chen He, Li-He Zhang, and De-Min Zhou
12 siRNA: THE SPECIFICITY AND OFF-TARGET EFFECTS 405
Quan Du, Huang Huang, and Zicai Liang
INDEX 423

Über Autor(innen)

LI-HE ZHANG is President of the academic committee of StateKey Laboratory of Natural and Biomimetic Drugs, as well asProfessor of Medicinal Chemistry at Peking University. He is also amember of the Chinese Academy of Sciences, Fellow of the RoyalSociety of Chemistry, former vice president of the ChinesePharmaceutical Association, and past president of the AsianFederation of Medicinal Chemistry.
ZHEN XI, PhD, is Deputy Director of the State KeyLaboratory of Elemento-organic Chemistry, as well as Professor ofPesticide Science and Chemical Biology, and Vice Dean of theCollege of Chemistry at Nankai University. He holds seven patentsand has written a number of reviews and book chapters andsixty-four original research articles.
JYOTI CHATTOPADHYAYA, PhD, DSc, is the University Chairof Bioorganic Chemistry and the chair of the Chemical BiologyProgram at Uppsala University. He is a guest professor of chemistryat both Jilin University and Nankai University. He has written over410 peer-reviewed original research articles and is also on theeditorial boards of several international journals.