DNA Replication - Damage from Environmental Carcinogens

2015
ISBN: 978-94-017-7211-2
Verlag: Springer Netherlands

Buch, Englisch, Band 17, 43 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 1109 g

Reihe: SpringerBriefs in Biochemistry and Molecular Biology

This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health.

Zielgruppe

Research

Autoren/Hrsg.

Zhang, Huidong

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen
• Naturwissenschaften Biowissenschaften Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Public Health, Gesundheitsmanagement, Gesundheitsökonomie, Gesundheitspolitik

Inhaltsverzeichnis

DNA replication.- Disturbances of the DNA replication system.- Fate of DNA replisome upon encountering DNA damage.- External Causes for DNA Damage.- Effect of environmental carcinogens on cellular physiology.- Protocols for studies of bypass of DNA damage by DNA polymerase.

Über Autor(innen)

Dr. Huidong Zhang is a professor and assistant director of the Institute of Toxicology, Preventive Medical College, Third Military Medical University in China, and the winner of China’s “Thousand Youth Talents Plan.” His research focuses on DNA damage and replication, and he has published more than 20 original research articles in international peer-reviewed journals such as the PNAS, JBC and Cell Cycle.