Yurchenco Extracellular Matrix Assembly and Structure

1. Auflage 2013
ISBN: 978-1-4832-8942-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 468 Seiten, Web PDF

Reihe: Biology of Extracellular Matrix

The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix. - Addresses assembly of most of the known classes of extracellular matrix macromolecules - Discusses higher order structures produced by ECM - Gives important concepts in ECM and cell-matrix interactions, Protein structure and protein-protein interactions, Development and tissue remodeling

Autoren/Hrsg.

Yurchenco, Peter D.

Inhaltsverzeichnis

1;Front Cover;1
2;Extracellular Matrix Assembly and Structure;4
3;Copyright Page;5
4;Table of Contents;6
5;CONTRIBUTORS;10
6;PREFACE;12
7;Chapter 1. Concepts of Self-Assembly in Biological Systems;14
7.1;I. Introduction;14
7.2;II. Linear Aggregation Models;15
7.3;III. Equilibrium Treatment;16
7.4;IV. Kinetics;20
7.5;V. Size Distributions;21
7.6;VI. Steady State and Fluctuations;24
7.7;VII. Outlook;25
7.8;ACKNOWLEDGMENT S;26
7.9;References;26
8;Chapter 2. Fundamentals of Interstitial Collagen Self-Assembly;28
8.1;I. Introduction;28
8.2;II. Fibril-Forming Collagens;29
8.3;III. In Vitro Self-Assembly;43
8.4;IV. Concluding Remarks;54
8.5;References;55
9;Chapter 3. Assembly of Collagen Fibrils de Novo from Soluble Precursors: Polymerization and Copolymerization of Procollagen, pN-Collagen, and Mutated Collagens;60
9.1;I. Introduction;60
9.2;II. Procollagen Propeptides: Contributions to Solubility and Form;62
9.3;III. Fibril Formation de Novo;70
9.4;IV. Conclusions;96
9.5;ACKNOWLEDGMENTS;97
9.6;References;98
10;Chapter 4. Collagen Fibril Assembly, Deposition, and Organization into Tissue-Specific Matrices;104
10.1;I. Introduction;104
10.2;II. Fibril Assembly;105
10.3;III. Fibril Deposition;126
10.4;ACKNOWLEDGMENTS;141
10.5;References;141
11;Chapter 5. Heterotypic Type II, IX, and XI Fibrils: Comparison of Vitreous and Cartilage Forms;144
11.1;I. Introduction;144
11.2;II. Cartilage Heterotypic Collagen Fibrils: Composition and Organization;146
11.3;III. Fibrillar Collagens;148
11.4;IV. Type IX Collagen;152
11.5;V. Other Fibril-Associated Components;159
11.6;VI. Vitreous Humor Collagens;161
11.7;VII. Summary;172
11.8;ACKNOWLEDGMENTS;172
11.9;References;172
12;Chapter 6. Assembly of Type X Collagen by Hypertrophic Chondrocytes;186
12.1;I. Introduction;186
12.2;II. Type X Collagen: Marker for the Maturation of Chondrocytes;187
12.3;III. Type X Collagen Structure;189
12.4;IV. Ultrastructural Assembly of Type X Collagen;192
12.5;V. Temporary Scaffold: Disassembly of the Hypertrophic Cartilage Matrix;199
12.6;VI. Calcification of Cartilage;204
12.7;VII. Environmental Modulation of Type X Collagen Synthesis;208
12.8;VIII. Type X Collagen as a Potential Regulatory Molecule in Cartilage;211
12.9;ACKNOWLEDGMENTS;215
12.10;References;215
13;Chapter 7. Microfibrillar Collagen Type VI;222
13.1;I. Introduction;222
13.2;II. Protein Assembly and Microfibrillar Model;223
13.3;III. Ultrastructural Evidence for Microfibrils and Heterotypic Interactions;227
13.4;IV. Domain Predictions from the Sequence;233
13.5;V. Recombinant Approaches to Structure and Function;237
13.6;VI. Integrin-Mediated Cell Adhesion;240
13.7;VII. Properties of the Genes;241
13.8;VIII. Modulation of Expression and Tissue Distribution;244
13.9;IX. Conclusions;248
13.10;ACKNOWLEDGMENTS;248
13.11;References;249
14;Chapter 8. Glycosaminoglycans and Proteoglycans;258
14.1;I. Introduction;258
14.2;II. Proteoglycans;259
14.3;III. Ultrastructural Appearance of Glycosaminoglycans and Proteoglycans in Tissue;261
14.4;IV. In Vitro Interactions of Glycosaminoglycans and Proteoglycans with Extracellular Matrix Compounds;272
14.5;V. Functions of Proteoglycans in the Extracellular Matrix;281
14.6;VI. Concluding Remarks;287
14.7;ACKNOWLEDGMENTS;288
14.8;References;288
15;Chapter 9. Elastic Fiber Structure and Assembly;296
15.1;I. Introduction;296
15.2;II. Elastin Fiber Composition;298
15.3;III. Primary Structure of Tropoelastin;303
15.4;IV. Secondary Structure of Tropoelastin Domains;308
15.5;V. Elastic Fiber Assembly;315
15.6;VI. Ultrastructural Organization of Elastic Fibers;319
15.7;ACKNOWLEDGMENTS;325
15.8;References;325
16;Chapter 10. Formation of Fibronectin Extracellular Matrix;330
16.1;I. Introduction to Fibronectin;330
16.2;II. Assembly of Fibronectin;338
16.3;III. Relationship of Other Matrix Molecules to Fibronectin Matrix;352
16.4;IV. Regulation of Matrix Assembly Sites;353
16.5;References;355
17;Chapter 11. Assembly of Laminin and Type IV Collagen into Basement Membrane Networks;366
17.1;I. Introduction;366
17.2;II. Laminin and Self-Assembly;371
17.3;III. Type IV Collagen and Self-Assembly;382
17.4;IV. Double Polymer Scaffolding of Basement Membranes;388
17.5;V. Other Interactions;391
17.6;VI. Alterations of Basement Membrane Scaffolding in Disease;392
17.7;VII. Conclusions;395
17.8;ACKNOWLEDGMENTS;396
17.9;References;396
18;Chapter 12. Nidogen: A Versatile Binding Protein of Basement Membranes;404
18.1;I. Introduction;404
18.2;II. Domain Structure and Metabolism;405
18.3;III. Regulation of Expression and Tissue Distribution;413
18.4;IV. Nidogen Binding to Protein Ligands;415
18.5;V. Affinity for Calcium and Other Cations;422
18.6;VI. Cooperation of Binding Sites;423
18.7;VII. Perspectives;425
18.8;ACKNOWLEDGMENTS;426
18.9;References;426
19;Chapter 13. Hemidesmosomes, Anchoring Filaments, and Anchoring Fibrils: Components of a Unique Attachment Complex;432
19.1;I. Introduction;432
19.2;II. Components of the Hemidesmosome;434
19.3;III. Assembly of Hemidesmosomes;442
19.4;IV. Anchoring Filaments;444
19.5;V. Anchoring Fibrils and Anchoring Plaques;445
19.6;VI. Inherited Defects in the Anchoring Complex;446
19.7;VII. Concluding Remarks;448
19.8;ACKNOWLEDGMENTS;449
19.9;References;449
20;Chapter 14. Interstitial Basement Membrane Components in Development ;456
20.1;I. Introduction;456
20.2;II. Morphogenetic Movements: Developing Intestine;458
20.3;III. Cell Migration: Neural Crest;459
20.4;IV. Branching Morphogenesis: Lung and Salivary Gland;461
20.5;V. Matrix Stabilization: Cornea;462
20.6;VI. Concluding Remarks;471
20.7;ACKNOWLEDGMENT;473
20.8;References;473
21;INDEX;478