Buch, Englisch, 334 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 540 g
Buch, Englisch, 334 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 540 g
Reihe: Statistics for Biology and Health
ISBN: 978-1-4419-2385-1
Verlag: Springer
Gene mapping is used in experimental genetics to improve the hardiness or productivity of animals or plants of agricultural value, to explore basic mechanisms of inheritance, or to study animal models of human inheritance. In human populations it is used as a first step to identify genes associated with human health and disease. This book presents a unified discussion of the statistical concepts applied in gene mapping, first in the experimental context of crosses of inbred lines and then in outbred populations, primarily humans. The development involves elementary principles of probability and statistics, which are implemented by computational tools based on the R programming language to simulate genetic experiments and evaluate statistical analyses. The viewpoint reflects the modern approach of using anonymous DNA markers distributed throughout the genome to identify regions likely to contain genes of interest. The reader is assumed to have some familiarity with probability/statistics and with elementary genetics. Important topics are reviewed in the first three chapters. The R programming language is developed in the text. Each chapter contains exercises, both theoretical and computational, some routine and others that are more challenging. The book is suitable for upper level undergraduate students or graduate students of genetics or statistics.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Biowissenschaften Molekularbiologie
- Mathematik | Informatik EDV | Informatik Programmierung | Softwareentwicklung Grafikprogrammierung
- Interdisziplinäres Wissenschaften Wissenschaften: Forschung und Information Datenanalyse, Datenverarbeitung
- Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
- Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
- Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
- Naturwissenschaften Biowissenschaften Botanik Pflanzenreproduktion, Verbreitung, Genetik
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
- Mathematik | Informatik Mathematik Numerik und Wissenschaftliches Rechnen Angewandte Mathematik, Mathematische Modelle
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizinische Mathematik & Informatik
- Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tiergenetik, Reproduktion
Weitere Infos & Material
Background and Preparations.- Background in Statistics.- to Experimental Genetics.- Fundamentals of Genetics: Inbreeding, Recombination, Random Mating, and Identity by Descent.- Experimental Genetics.- Testing for Linkage with a Single Marker.- Whole Genome Scans: The Significance Level.- Statistical Power and Confidence Regions.- Missing Data and Interval Mapping.- Advanced Topics.- Human Genetics.- Mapping Qualitative Traits in Humans Using Affected Sib Pairs.- Admixture Mapping.- Mapping Complex and Quantitative Traits with Data from Human Pedigrees.- Association Studies.- Inferring Haplotypes from Genotypes and Testing Association.
