Witt Protein Chaperones and Protection from Neurodegenerative Diseases

1. Auflage 2011
ISBN: 978-1-118-06388-0
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 444 Seiten, E-Book

Reihe: Wiley Series in Protein and Peptide Science

How protein chaperones protect cells from neurodegenerativediseases
Including contributions from leading experts, Protein Chaperonesand Protection from Neurodegenerative Diseases provides an in-depthexploration of how protein chaperones are involved in shieldingcells from toxic aggregated or misfolded protein states that causeALS, Parkinson's, and related diseases.
Examining how different protein chaperones ameliorate thetoxicity of proteins that are known to cause neurodegenerativedamage, the book addresses both research and clinical perspectiveson chaperone and anti-chaperone properties. The intersection ofmolecular chaperones and neurodegeneration is an intensely studiedarea, partly because of the potential for manipulating theexpression of molecular chaperones to thwart the progression ofdebilitating diseases, and partly because of the ever-aging globalpopulation.
Discussing the potential to harness the power of proteinchaperones, and future directions for research, discovery, andtherapeutics, this book is essential reading for scientists workingin the fields of biochemistry, molecular medicine, pharmacology anddrug discovery, biotechnology and pharmaceutical companies,advanced students, and anyone interested in this cutting-edgetopic.

Autoren/Hrsg.

Witt, Stephan N.

Weitere Mitwirkende

Uversky, Vladimir

Inhaltsverzeichnis

Preface.
Introduction.
Contributors.
1 Intrinsically Disordered Chaperones and Neurodegeneration(Vladimir N. Uversky).
2 Redox Regulation of Protein Misfolding, Synaptic Damage,and Neuronal Loss in Neurodegenerative Diseases (TomohiroNakamura and Stuart A. Lipton).
3 Chaperone-Mediated Autophagy and Parkinson's Disease(Marta Martinez-Vicente and Ester Wong).
4 Chaperone and Anti-Chaperone Properties of Synuclein:Implications for Development, Aging, and Neurodegenerative Disease(Makoto Hashimoto, Kazuanri Sekiyama, Akio Sekigawa, andMasayo Fujita).
5 The Ubiquitin-Proteasome System in NeurodegenerativeDiseases: More than the Usual Suspects (AnneBertolotti).
6 Regulation of the Polyglutamine Androgen Receptor by theHsp90/Hsp70-Based Chaperone Machinery (Andrew P. Liebermanand William B. Pratt).
7 Amyloid Remodeling by Hsp104 (JamesShorter).
8 Chaperone-Dependent Amyloid Assembly and Prion Toxicity(Daniel W. Summers, Katie J. Wolfe, and Douglas M.Cyr).
9 Modulation of Amyloid Propagation in Yeast by Hsp70 and itsRegulators and Chaperone Partners (Daniel C.Masison).
10 ALS and the Copper Chaperone CCS (Marjatta Son andJeffrey L. Elliott).
11 Emerging Area: TorsinA, a Novel ATP-Dependent FactorLinked to Dystonia (Michal Zolkiewski and Hui-ChuanWu).
12 Therapeutics: Harnessing the Power of Molecular andPharmacological Chaperones (David S. Gross, Ronald L. Kleinand Stephan N. Witt).
Index.

Über Autor(innen)

Stephan N. Witt is a Professor in the Department of Biochemistryand Molecular Biology at the Louisiana State University HealthSciences Center in Shreveport, Louisiana. He obtained his PhD inbiophysical chemistry from the California Institute ofTechnology.??Dr. Witt is a member of the editorial board of CellStress and Chaperones. He has served on numerous NIH studysections, has authored over forty scientific publications, andedited a book on using yeast as a model for human disease. Hisresearch focuses on identifying genes and small molecules that canbe used against Parkinson's disease.