SUMO Regulation of Cellular Processes

2009
ISBN: 978-94-007-9144-2
Verlag: Springer Netherland

Buch, Englisch, 339 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 539 g

Over a decade ago, a small cellular protein of 12 kDa, with 18% homology to the well-known ubiquitin protein, was co-discovered and termed Small Ubiquitin-like Modifier, or SUMO. Sumoylation is a post-translational modification that utilizes SUMO as the modifier group covalently attached to target substrates. This state-of-the art review on the sumoylation system deals with protein modification as it pertains to regulation of diverse cellular functions. Each chapter has been written by a leading researcher and covers the role of sumoylation in fundamental biochemical activities (transcription, RNA processing, chromatin remodelling, DNA repair, nucleocytoplasmic transport, ion channel regulation, and metabolic pathways). The text also examines the part sumoylation plays in critical cellular processes such as mitosis, meiosis, differentiation, senescence, and apoptosis. Lastly, the emerging role of sumoylation in specific diseases, including cancer and diabetes as well as neurodegenerative ones, is explored with an emphasis on defining molecular mechanisms that may provide new targets for treatment or prevention. While SUMO was discovered more than 10 years ago, this is still a relatively young field, and much remains to be discovered about the biochemical and biological properties of this modification system. In just the last few years, it has become clear that sumoylation modifies hundreds of cellular proteins, and there has been increased appreciation for the breadth of cellular functions that are impacted by this post-translational modification.

Zielgruppe

Research

Autoren/Hrsg.

Wilson, Van G.

Inhaltsverzeichnis

Chapter 1: Introduction to Sumoylation Molecular Functions Chapter 2: SUMO Modification and Transcriptional Regulation Chapter 3: Emerging Roles for SUMO in mRNA Processing and Metabolism Chapter 4: SUMO and Chromatin Remodeling Chapter 5: Functions of SUMO in the Maintenance of Genome Stability Chapter 6: SUMO and Nucleocytoplasmic Transport

Chapter 7: SUMO Modification of Ion Channels

Chapter 8: The Role of Sumolyation in Metabolic Regulation Cell Growth Regulation Chapter 9: The SUMO Pathway in Mitosis Chapter 10: Wrestling with Chromosomes: The Roles SUMO during Meiosis Chapter 11: Sumoylation in Development and Differentiation Chapter 12: The Role of Sumoylation in Senescence Chapter 13: Sumoylation and Apoptosis Diseases Chapter 14: The Role of Sumoylation in Neurodegenerative Diseases Chapter 15: Sumoylation and its Contribution to Cancer Chapter 16: SUMO4-encoded Genetic Susceptibility to Type 1 Diabetes Chapter 17: Sumoylation in Craniofacial Disorders Chapter 18: Viral Interplay with the Host Sumoylation System