Wiles / Watts Micro Reaction Technology in Organic Synthesis

1. Auflage 2011
ISBN: 978-1-4398-2472-6
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 453 Seiten

While continuous processes have found widespread application within chemical production, members of the research and development communities have historically favored the centuries old technique of iterative batch reactions. With the exception of combinatorial and microwave chemistry, little had been done to change the way that synthetic chemists conduct their research. However, today’s synthetic chemist is under increasing pressure to discover and deliver compounds quickly, with an eye on devising scalable synthetic methodologies.

An up-to-date account of recent developments in continuous flow organic synthesis, Micro Reaction Technology in Organic Synthesis is a useful resource for those both new to, and actively researching within, the field of micro reaction technology.

- Written by chemists for chemists, key synthetic information takes precedence over technological details

- Highlights the advantages and disadvantages of the technology, giving the reader an idea of where future research needs to be targeted

- Presents a comprehensive collection of synthetic reactions that have been investigated over the past decade, therefore is a one-stop resource to the reactions and techniques that have been investigated so far

With an ever increasing number of commercial flow reaction platforms available, this book highlights the current state of the technology with the vision that more synthetic chemists will embark upon flow chemistry programs of research, facilitating the identification of novel synthetic methodologies the potential to be scaled directly to production.

Zielgruppe

Organic chemists, researchers in the fine chemicals industry, formulation chemists, process chemists, chemical engineers, biochemists; and scientists in drug discovery, biotechnology, high performance materials, and composite materials.

Autoren/Hrsg.

Wiles, Charlotte

Watts, Paul

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Chemische Anlagen
• Geowissenschaften Umweltwissenschaften Umwelttechnik
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Verfahrenstechnik, Chemieingenieurwesen
• Technische Wissenschaften Umwelttechnik | Umwelttechnologie Umwelttechnik
• Naturwissenschaften Chemie Physikalische Chemie

Inhaltsverzeichnis

Introduction to Micro Reaction Technology

What is Micro Reaction Technology?

Fabrication/Construction of Micro Reactors

Manipulation of Reactants and Products within Flow Reactors

Advantages of Micro Reaction Technology

Disadvantages of Micro Reactors

Process Intensification

In Situ Reaction Monitoring

Commercial Availability of Continuous Flow
Outlook

References

Micro Reactions Employing a Gaseous Component

Gas-Phase Micro Reactions

Gas–Liquid-Phase Micro Reactions

Gas–Liquid–Solid Micro Reactions

References

Liquid-Phase Micro Reactions

Nucleophilic Substitution

Electrophilic Substitution

Nucleophilic Addition

Elimination Reactions

Oxidations
Reductions

Metal-Catalyzed Cross-Coupling Reactions

Rearrangements

Multistep/Multicomponent Liquid-Phase Reactions

Summary

References

Multi-Phase Micro Reactions

Nucleophilic Substitution
Electrophilic Substitution

Nucleophilic Addition

Elimination Reactions

Oxidation Reactions

Metal-Catalyzed Cross-Coupling Reactions

Rearrangements

Enantioselective Reactions

Multistep/Multicomponent Reactions

Summary

References

Electrochemical and Photochemical Applications of Micro Reaction Technology

Electrochemical Synthesis under Continuous Flow

Photochemical Synthesis under Continuous Flow

Multiphase Photochemical Reactions

References

The Use of Microfluidic Devices for the Preparation and Manipulation of Droplets and Inorganic/Organic Particles

Droplet Formation using Continuous Flow Methodology

Preparation of Inorganic Nanoparticles under Continuous Processing Conditions

Formation of Organic Particles within Continuous Flow Devices

The Use of Micro Reactors for the Postsynthetic Manipulation of Organic Compounds

Mixed Particle Formation

Summary

References

Industrial Interest in Micro Reaction Technology

MRT in Production Environments

Synthesis of Fine Chemicals Using Micro Reactors

Synthesis of Pharmaceuticals and Natural Products using Continuous Flow Methodology

Synthesis of Small Doses of Radiopharmaceuticals

Summary

References

Microscale Continuous Separations and Purifications

Introduction

Liquid–Liquid Extractions

Gas–Liquid Separation

Solvent Exchange and Solvent Removal

The Use of Scavenger Resins for Product Purification under Flow

Continuous Flow Resolutions

Product Isolation

Summary

References