The Cholinergic Synapse

Softcover Nachdruck of the original 1. Auflage 1988
ISBN: 978-3-642-73222-5
Verlag: Springer

Buch, Englisch, Band 86, 762 Seiten, Format (B × H): 170 mm x 242 mm, Gewicht: 1335 g

Reihe: Handbook of Experimental Pharmacology

One of the most impressive works of scholarship in the field of experimental pharmacology has been the Heffter-Heubner Handbuch der experimentellen Pharmakologie, internationalized some years ago under the title Handbook 0/ Experimental Pharmacology and kept up to date by a series of numbered Ergiin­ zungswerke or supplementary volumes which have now replaced in importance the original Handbuch. These volumes constitute a valuable and continuously up­ dated multi author review series of topics important in modern pharmacology and allied sciences. The Editorial Board of the Handbook invited me 2 years ago to undertake, as subeditor, the preparation of a new volume entitled The Cholinergic Synapse. A previous volume in this series, vol. 15, Cholinesterases and Anticholinesterase Agents, edited by GEORGE KOELLE, was published in 1963 and was far wider in scope than its title suggested: it was, in fact an authoritative summing up of the whole subject of cholinergic function and still has some value today as an account of the state of the art as it was at that time. Since then another excellent review, of a specific cholinergic synapse, has appeared in this series: this was vol. 42, Neuromuscular Junction, edited by ELEANOR ZAIMIS and published in 1976. A third volume, vol. 53, Pharmacology o/Ganglionic Transmission, which appeared in 1980 and was edited by D. A. KHARKEVICH, includes important aspects of autonomic cholinergic function.

Zielgruppe

Research

Autoren/Hrsg.

Whittaker, Victor P.

Inhaltsverzeichnis

I. Model Cholinergic Systems.- 1: Model Cholinergic Systems: An Overview.- 2: Model Cholinergic Systems: The Electromotor System of Torpedo.- 3: Model Cholinergic Systems: The Avian Ciliary Ganglion.- II. Biology of the Cholinergic Synapse.- 4: Phylogeny of the Cholinergic Synapse.- 5: Development of the Cholinergic Synapse: Role of Trophic Factors.- III. Molecular Components of the Cholinergic System.- 6: Estimation of Acetylcholine and Choline and Analysis of Acetylcholine Turnover Rates In Vivo.- 7: Choline Acetyltransferase and the Synthesis of Acetylcholine.- 8a: Vertebrate Cholinesterases: Structure and Types of Interaction.- 8b: Cholinesterases: Tissue and Cellular Distribution of Molecular Forms and Their Physiological Regulation.- 9: Structure and Function of the Nicotinic Acetylcholine Receptor.- 10: Muscarinic Acetylcholine Receptors.- IV. Cellular Organization of the Cholinergic System.- 11: Cholinergic Synaptic Vesicles.- 12: Isolation of Cholinergic Nerve Terminals.- 13: Axonal Transport in Cholinergic Neurons.- 14: The High-Affinity Choline Uptake System.- 15: Cholinergic-Specific Antigens.- 16: Cholinergic False Transmitters.- 17: Cholinergic Co-transmitters.- V. Peripheral Cholinergic Synapses.- 18: The Neuromuscular Junction.- 19: The Electromotor Synapse.- 20: The Autonomic Cholinergic Neuroeffector Junction.- VI. Central Cholinergic Systems.- 21: Central Cholinergic Pathways: The Biochemical Evidence.- 22: Central Cholinergic Pathways: The Histochemical Evidence.- 23: Central Cholinergic Transmission: The Physiological Evidence.- VII. Neuropathology of Cholinergic Transmission.- 24: The Cholinergic System in Aging.- 25: Disorders of Cholinergic Synapses in the Peripheral Nervous System.- 26: Central Cholinergic Neuropathologies.