This book is about the dynamics of neural systems and should be suitable for those with a background in mathematics, physics, or engineering who want to see how their knowledge and skill sets can be applied in a neurobiological context. No prior knowledge of neuroscience is assumed, nor is advanced understanding of all aspects of applied mathematics! Rather, models and methods are introduced in the context of a typical neural phenomenon and a narrative developed that will allow the reader to test their understanding by tackling a set of mathematical problems at the end of each chapter. The emphasis is on mathematical- as opposed to computational-neuroscience, though stresses calculation above theorem and proof. The book presents necessary mathematical material in a digestible and compact form when required for specific topics. The book has nine chapters, progressing from the cell to the tissue, and an extensive set of references. It includes Markov chain models for ions,differential equations for single neuron models, idealised phenomenological models, phase oscillator networks, spiking networks, and integro-differential equations for large scale brain activity, with delays and stochasticity thrown in for good measure. One common methodological element that arises throughout the book is the use of techniques from nonsmooth dynamical systems to form tractable models and make explicit progress in calculating solutions for rhythmic neural behaviour, synchrony, waves, patterns, and their stability. This book was written for those with an interest in applied mathematics seeking to expand their horizons to cover the dynamics of neural systems. It is suitable for a Masters level course or for postgraduate researchers starting in the field of mathematical neuroscience.
Wedgwood / Coombes
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Weitere Infos & Material
Overview.- Single neuron models-. Phenomenological models and their analysis.- Axons, dendrites, and synapses.- Response properties of single neurons.- Weakly coupled oscillator networks.- Strongly coupled spiking networks.- Population models.- Firing rate tissue models.- Stochastic calculus.- Model Details.- References.
Stephen Coombes is a Professor of Applied Mathematics at the University of Nottingham, UK. His research interest is in the use of nonlinear dynamics to understand aspects of the human central nervous system. He has co-edited two books and authored over 120 peer-reviewed journal articles. He has supervised 22 PhD students and 8 postdoctoral fellows.Together with colleagues in Mathematics and Neuroscience he is actively pursuing research projects ranging from single cell dynamics to neuronal circuits to whole-brain dynamics with applications in psychology, neuroimaging, medicine, and psychiatry.
Kyle Wedgwood is a Lecturer in Mathematics in the Living Systems Institute at the University of Exeter, UK. He applies techniques from dynamical systems theory to understand how electrically excitable cells produce coherent rhythms in networks and has authored 22 peer-reviewed journal articles. He currently supervises 4 PhD students and 2 postdoctoral fellows. In his current research, he is exploring how mathematics can be embedded in neuroscience experiments.
