Weber Molecular Aspects of Animal Development

1. Auflage 2014
ISBN: 978-1-4832-7271-9
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 525 Seiten, Web PDF

The Biochemistry of Animal Development, Volume III: Molecular Aspects of Animal Development provides an account of the developments in the molecular approach to vertebrate development with particular emphasis on the functions of nucleic acids. The book discusses topics on oocyte maturation, transcriptional patterns in early development, the post-transcriptional control of gene expression, and the significance of gene amplification. Morphogenetic substances, growth-promoting proteins, and the functional differentiation of mitochondria in embryonic systems are covered as well. Biochemists, biologists, and zoologists will find the book invaluable.

Autoren/Hrsg.

Weber, Rudolf

Inhaltsverzeichnis

1;Front Cover;1
2;Molecular Aspects of Animal Development;4
3;Copyright Page;5
4;Table of Contents;6
5;Contributors to Volume III;10
6;Preface;12
7;Contents of Previous Volumes;14
8;CHAPTER 1. Molecular Events during Oocyte Maturation;18
8.1;I. Introduction;18
8.2;II. The Induction of Maturation;20
8.3;III. Morphological Events of Maturation and Their Relationship to Early Development;22
8.4;IV. Macromolecular Synthesis during Maturation;30
8.5;V. Characterization of Hormone-Oocyte Interactions in the Induction of Maturation;44
8.6;VI. Concluding Comments;57
8.7;References;59
9;CHAPTER 2. Transcriptional Patterns in Early Mammalian Development;64
9.1;I. General Introduction;65
9.2;II. Onset of Gene Activity in Preimplantation Mammalian Embryos;67
9.3;III. RNA Containing Poly(A) Sequences in Preimplantation Rabbit Embryos;73
9.4;IV. Complexity of Transcription in Developing Mammals;79
9.5;V. Mechanisms of Transcriptional Control;94
9.6;VI. Relationship of Transcriptional Changes to the General Biochemistry of the Preimplantation Embryo;98
9.7;VII. Concluding Remarks;102
9.8;References;103
10;CHAPTER 3. Occurrence and Developmental Significance of Gene Amplification;108
10.1;I. Introduction;108
10.2;II. Gene Amplification versus Gene Reiteration;114
10.3;III. Occurrence of Gene Amplification;117
10.4;IV. Visualization of Gene Amplification;141
10.5;V. Possible Mechanisms of Gene Amplification;144
10.6;VI. Theories on Developmental Significance;151
10.7;VII. Summary and Concluding Remarks;152
10.8;References;153
11;CHAPTER 4. The Injection of RNA into Living Cells: The Use of Frog Oocytes for the Assay of mRNA and the Study of the Control of Gene Expression;162
11.1;I. Introduction;162
11.2;II. The Translation and Assay of mRNA's;164
11.3;III. Quantitative Studies: The Efficiency of Translation of Injected mRNA;175
11.4;IV. The Fidelity of Translation of Injected mRNA's;180
11.5;V. The Specificity of the Translational Machinery of the Oocyte;180
11.6;VI. The Post-Translational Modification of Messenger Products;188
11.7;VII. mRNA Injection as a Means for Analyzing the Translational Systems of the Living Cell;191
11.8;VIII. Translation of mRNA-Precursor Molecules;194
11.9;References;196
12;CHAPTER 5. Post-Transcriptional Control of Protein Synthesis;200
12.1;I. Introduction;200
12.2;II. Evidence for Translational Control of Protein Synthesis in Bacteria;204
12.3;III. Evidence for Post-Transcriptional Control of Protein Synthesis in Animal Cells;208
12.4;IV. Concluding Remarks;227
12.5;References;229
13;CHAPTER 6. The Control of Isoenzyme Patterns in Development;234
13.1;I. Introduction;234
13.2;II. Isoenzyme Biochemistry: A General Introduction;235
13.3;III. Isoenzyme Distribution;243
13.4;IV. Mechanisms of Control of Isoenzyme Expression during Development;255
13.5;V. Concluding Remarks;267
13.6;References;268
14;CHAPTER 7. Substances with Morphogenetic Activity in Differentiation of Vertebrates;274
14.1;I. Introduction;275
14.2;II. Determination, Differentiation, and Competence;275
14.3;III. Evidence for the Existence of Special Morphogenetic Factors;277
14.4;IV. Chemical Properties, Biological Activity, and Mechanism of Action of
Morphogenetic Substances Effective in Early Embryogenesis;279
14.5;V. Induction and Determination in Normogenesis of Amphibian Embryos;292
14.6;VI. Stimulation of Hematopoiesis;297
14.7;VII. Nerve Growth Stimulating and Epithelial Growth Stimulating Factors;301
14.8;VIII. Concluding Remarks;303
14.9;References;304
15;CHAPTER 8. Protein Nutrition in Growth Regulation during Early Development;310
15.1;I. Introduction;310
15.2;II. The Requirement of Embryos for Nutrient Protein;312
15.3;III. The Requirement of Embryos for Specific Nutrient Proteins;320
15.4;IV. Nutrient Protein Complementation;326
15.5;V. Quantitative Analysis of Protein Utilization;336
15.6;VI. Protein Deprivation during Early Development;342
15.7;References;350
16;CHAPTER 9. Mitochondrial Differentiation during Animal Development;354
16.1;I. Introduction;354
16.2;II. Structure of Mitochondria;356
16.3;III. Enzyme Content of Mitochondria;359
16.4;IV. Mitochondrial Differentiation;362
16.5;V. Concluding Statement;395
16.6;References;396
17;CHAPTER 10. Occurrence and Possible Functions of Mitochondrial DNA in Animal Development;404
17.1;I. Introduction;405
17.2;II. Cytoplasmic DNA;406
17.3;III. Replication and Stability of mt DNA;418
17.4;IV. Transcription of mt DNA;428
17.5;V. Mitochondrial Protein Synthesis;438
17.6;VI. The Possible Results of Interfering with the Mammalian Mitochondrial Genome;462
17.7;VII. Concluding Remarks;470
17.8;References;472
18;AUTHOR INDEX;482
19;INDEX TO GENUS AND SPECIES NAMES;506
20;SUBJECT INDEX;508