Precision Medicine, AI and the Science of Personalized Healthcare

1. Auflage 2025
ISBN: 978-1-394-34158-0
Verlag: Wiley

Buch, Englisch, 352 Seiten

A fascinating combination of patient stories and scientific explanation shedding light on the most promising trend in healthcare today: precision medicine

In Precision Medicine, AI and the Science of Personalized Healthcare, senior researcher at Harvard Business School and former CEO of DecisionRx, a pioneering medication therapy optimization company, James Wallace, delivers an eye-opening new discussion of how cutting-edge precision medicine is transforming the cost, access, and outcomes of modern healthcare. The author relies on real-world experiences that showcase the practical, human benefits of precision medicine and how those benefits can accrue to people from all walks of life.

You'll discover how personalized treatments—those based on a patient's genetic, environmental, and lifestyle attributes—can do more than traditional medicine to combat a wide variety of genetic disorders, chronic illnesses, and treatment inefficiencies. You'll also learn about precision medicine's potential to lower healthcare costs for everyone while improving outcomes.

Inside the book:

- Explorations of how precision medicine can address the triple crisis of cost, access, and quality that currently plagues the US healthcare system
- Unique combinations of compelling human stories and accessible scientific explanations that render a complex subject approachable and relatable
- A compelling argument for how the precision medicine movement can transform the healthcare system and the lives of the people who navigate it every day

Perfect for healthcare, technology, and business professionals grappling with the skyrocketing costs of patient care, Precision Medicine, AI and the Science of Personalized Healthcare is also a must-read for healthcare consumers frustrated by the current, “one-size-fits-all” approach to medicine.

Autoren/Hrsg.

Wallace, James

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizinische Mathematik & Informatik
• Mathematik | Informatik EDV | Informatik Informatik Künstliche Intelligenz

Inhaltsverzeichnis

Foreword xvii Preface xix Introduction: The Dawn of a New Era xxi Chapter 1 Michael and Jennifer: A Family’s Fight Against Obesity 1 Michael: The Silent Fighter 3 Jennifer: The Hopeful Realist 6 The Wearable Catalyst 10 A Hopeful Future 19 Chapter 2 Wearable Devices 21 Chronic Conditions: A Growing Concern 22 Wearables and Precision Medicine: Tailoring Health Solutions 28 Costs and Outcomes of Wearable Devices: Traditional vs. Precision Medicine 42 Notes 53 Chapter 3 The Science of Hope 59 Simplifying Precision Medicine 60 How It Works: From Data to Decisions 60 The Patient Perspective: Benefits Made Simple 62 Understanding the Impact of Wearables, Pharmacogenomics, Big Data Analytics, and Artificial Intelligence 65 Macro-Level Cost and Outcomes 70 The Universal Benefits of Precision Medicine 75 Notes 80 Chapter 4 Emily’s Unrest 85 A Life of Contrasts 85 Breaking Point 93 Pharmacogenomics: A Tailored Solution 100 A Renewed Emily 103 Chapter 5 Genetics and Medication Management 107 Medication Failure in Traditional Care 108 Precision Medicine’s Approach: Eliminating Trial and Error 113 The Role of Pharmacogenomics in Precision Medicine 122 Comparison of Cost and Outcomes: Traditional vs. Precision Medicine 129 Notes 134 Chapter 6 Through the Lens Clearly 141 Assembling the Pieces: The History of Medical Innovation 142 Implementing the Insights: From Bloodletting to Precision Medicine 152 Integrating the Outcomes: The Rise of Individualized Care 158 Notes 164 Chapter 7 The Joy and Pain of Being Amy 167 The Value of Work 168 A Lifetime of Shrugged Shoulders 172 A Voice of Concern 175 Treating the Person, Not the Symptoms 176 The Power of Knowing Why 177 It Takes a Village 180 Chapter 8 Pain and Personalized Therapy 185 The Hidden Epidemic of Pain 186 Data as Cure 191 Precision Pain Management in Action 198 Cost and Outcomes of Precision Pain Management 200 Notes 205 Chapter 9 Barriers to Access 209 The Challenges of Precision Medicine 210 Social Determinants of Health and Access to Care 217 Notes 221 Chapter 10 Susan, Family, and Cancer 223 Peggy Sue Got Married 223 The Family Years 225 Tuesday Afternoon 226 A Different Kind of Doctor 228 The Machine That Thinks 229 Moving the Mountain 232 A Life Reclaimed 234 Chapter 11 Artificial Intelligence and the Human Genome 237 The Intersection of Information and Artificial Intelligence 238 Genetic and Genomic Medicine 242 Cost and Outcomes: Advanced Personalized Treatments 252 Companies Shaping the Future of AI-Enabled Medicine 259 Notes 263 Chapter 12 A Vision for the Future 271 What’s Next for Precision Medicine 272 Implications for Traditional Medicine 277 How Precision Medicine Will Shape Personalized Healthcare 283 Notes 287 Conclusion: Making Medicine Personal 291 The Personal Healthcare Journey 291 Common Themes from our Guides: What We Can Learn 294 How You Can Explore Precision Medicine for Yourself 296 Call to Action: A Roadmap for Leaders, Investors, and Policymakers 299 Notes 302 Acknowledgments 303 About the Author 305 Index 307 Foreword xvii Preface xix Introduction: The Dawn of a New Era xxi Chapter 1 Michael and Jennifer: A Family’s Fight Against Obesity 1 Michael: The Silent Fighter 3 Jennifer: The Hopeful Realist 6 The Wearable Catalyst 10 A Hopeful Future 19 Chapter 2 Wearable Devices 21 Chronic Conditions: A Growing Concern 22 Wearables and Precision Medicine: Tailoring Health Solutions 28 Costs and Outcomes of Wearable Devices: Traditional vs. Precision Medicine 42 Notes 53 Chapter 3 The Science of Hope 59 Simplifying Precision Medicine 60 How It Works: From Data to Decisions 60 The Patient Perspective: Benefits Made Simple 62 Understanding the Impact of Wearables, Pharmacogenomics, Big Data Analytics, and Artificial Intelligence 65 Macro-Level Cost and Outcomes 70 The Universal Benefits of Precision Medicine 75 Notes 80 Chapter 4 Emily’s Unrest 85 A Life of Contrasts 85 Breaking Point 93 Pharmacogenomics: A Tailored Solution 100 A Renewed Emily 103 Chapter 5 Genetics and Medication Management 107 Medication Failure in Traditional Care 108 Precision Medicine’s Approach: Eliminating Trial and Error 113 The Role of Pharmacogenomics in Precision Medicine 122 Comparison of Cost and Outcomes: Traditional vs. Precision Medicine 129 Notes 134 Chapter 6 Through the Lens Clearly 141 Assembling the Pieces: The History of Medical Innovation 142 Implementing the Insights: From Bloodletting to Precision Medicine 152 Integrating the Outcomes: The Rise of Individualized Care 158 Notes 164 Chapter 7 The Joy and Pain of Being Amy 167 The Value of Work 168 A Lifetime of Shrugged Shoulders 172 A Voice of Concern 175 Treating the Person, Not the Symptoms 176 The Power of Knowing Why 177 It Takes a Village 180 Chapter 8 Pain and Personalized Therapy 185 The Hidden Epidemic of Pain 186 Data as Cure 191 Precision Pain Management in Action 198 Cost and Outcomes of Precision Pain Management 200 Notes 205 Chapter 9 Barriers to Access 209 The Challenges of Precision Medicine 210 Social Determinants of Health and Access to Care 217 Notes 221 Chapter 10 Susan, Family, and Cancer 223 Peggy Sue Got Married 223 The Family Years 225 Tuesday Afternoon 226 A Different Kind of Doctor 228 The Machine That Thinks 229 Moving the Mountain 232 A Life Reclaimed 234 Chapter 11 Artificial Intelligence and the Human Genome 237 The Intersection of Information and Artificial Intelligence 238 Genetic and Genomic Medicine 242 Cost and Outcomes: Advanced Personalized Treatments 252 Companies Shaping the Future of AI-Enabled Medicine 259 Notes 263 Chapter 12 A Vision for the Future 271 What’s Next for Precision Medicine 272 Implications for Traditional Medicine 277 How Precision Medicine Will Shape Personalized Healthcare 283 Notes 287 Conclusion: Making Medicine Personal 291 The Personal Healthcare Journey 291 Common Themes from our Guides: What We Can Learn 294 How You Can Explore Precision Medicine for Yourself 296 Call to Action: A Roadmap for Leaders, Investors, and Policymakers 299 Notes 302 Acknowledgments 303 About the Author 305 Index 307

Über Autor(innen)

JAMES WALLACE is the former CEO of DecisionRx, a medication therapy optimization company. He is a Senior Researcher at Harvard Business School. Wallace was previously the Head of Strategy for Anthem, the President of AmeriPlus, a combat pilot with the United States Army, and a strategy consultant with Bain & Company.