Walhout / Vidal / Dekker Handbook of Systems Biology

Concepts and Insights
1. Auflage 2012
ISBN: 978-0-12-385945-7
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 552 Seiten

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. - 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards - Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines - Includes the latest research developments in human and animal models to assist with translational research - Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Autoren/Hrsg.

Walhout, Marian

Vidal, Marc

Dekker, Job

Leseproben

List of Contributors
Réka Albert, Department of Physics, The Pennsylvania State University, University Park, PA 16802, USA, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA Brenda Andrews, Banting and Best Department of Medical Research, The Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada Gary D. Bader, The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada Heather Ballance, Department of Pharmacology, Penn Center for Bioinformatics, Penn Genome Frontiers Institute, Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA Albert-László Barabási, Center for Complex Network Research, Department of Physics, Northeastern University, 360 Huntington avenue, Boston, MA 02115, USA, Center for Cancer System Biology (CCSB) and Department of Cancer Biology, The Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02215, USA Baruch Barzel, Center for Complex Network Research, Department of Physics, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA, Center for Cancer System Biology (CCSB) and Department of Cancer Biology, The Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02215, USA Anastasia Baryshnikova, Banting and Best Department of Medical Research, The Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada Philippe I.H. Bastiaens, Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany Philip N. Benfey, Department of Biology and Duke Center for Systems Biology, Duke University, Durham, NC 27708, USA Charles Boone, Banting and Best Department of Medical Research, The Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada Kristin R. Brogaard, Institute for Systems Biology, 401 N. Terry Ave, Seattle, WA 98121, USA Martha L. Bulyk, Division of Genetics, Department of Medicine; Department of Pathology; Brigham & Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA & Harvard-MIT Division of Health Sciences and Technology (HST), Harvard Medical School, Boston, MA 02115, USA Michael A. Calderwood, Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA Anne-Ruxandra Carvunis, Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA Juan I. Castrillo, Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK Michael Costanzo, Banting and Best Department of Medical Research, The Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada Jürgen Cox, Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany Michael E. Cusick, Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA Eric H. Davidson, Division of Biology, MC 156–29, California Institute of Technology, Pasadena, CA 91125, USA Mark M. Davis, Department of Microbiology & Immunology, Howard Hughes Medical Institute, Beckman Center, Room B221, Stanford University School of Medicine, Stanford, CA 94305, USA Job Dekker, Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA Mauricio A. Flores, P4 Medicine Institute, 401 N. Terry Ave, Seattle, WA 98121, USA Andrew Fraser, The Donnelly Centre, University of Toronto, 160 College Street, Ontario M5S 3E1, Canada Guri Giaever, The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada, Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada Bruno Gonçalves, College of Computer and Information Sciences and Bouvé College of Health Sciences, Northeastern University, Boston, MA 02115, USA Hernán E. Grecco, Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany Roderic Guigó, Centre de Regulació Genòmica Universitat Pompeu Fabra, Dr Aiguader, 88, E-08003 Barcelona, Catalonia, Spain, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Dr Aiguader, 88, E-08003 Barcelona, Catalonia, Spain Hooman Hefzi, Bioengineering Department, University of California San Diego, La Jolla, CA 92093-0412, USA Marco Y. Hein, Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany John B. Hogenesch, Department of Pharmacology, Penn Center for Bioinformatics, Penn Genome Frontiers Institute, Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA Leroy Hood, Institute for Systems Biology, 401 N. Terry Ave, Seattle, WA 98121, USA Ravi Iyengar, Department of Pharmacology and Systems Therapeutics and Systems Biology Center, New York Mount Sinai School of Medicine, New York, NY 10029, USA Hiroaki Kitano, The Systems Biology Institute, Tokyo, Japan; Okinawa Institute of Science and Technology; Sony Computer Science Laboratories, Inc., Tokyo, Japan; Department of Cancer Systems Biology, The Cancer Institute, Tokyo, Japan Meghana M. Kulkarni, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA Anna Y. Lee, The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada Ben Lehner, European Molecular Biology Laboratory (EMBL)-Centre for Genomic Regulation (CRG) Systems Biology Unit and Institució Catalana de Recerca i Estudis Avançats (ICREA), CRG, Universitat Pompeu Fabra (UPF), c / Dr Aiguader, 88, Barcelona 08003, Spain Ihor Lemischka, Department of Regenerative and Developmental Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA, Black Family Stem Cell Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA Nathan E. Lewis, Bioengineering Department, University of California San Diego, La Jolla, CA 92093-0412, USA, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA Avi Ma’ayan, Department of Pharmacology and System Therapeutics, Mount Sinai School of Medicine, Systems Biology Center New York, One Gustave L. Levy Place, New York, NY 10029, USA, Black Family Stem Cell Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA Matthias Mann, Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried,...