E-Book, Englisch, 368 Seiten
Wagner Robustness and Evolvability in Living Systems
Course Book
ISBN: 978-1-4008-4938-3
Verlag: De Gruyter
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, 368 Seiten
Reihe: Princeton Studies in Complexity
ISBN: 978-1-4008-4938-3
Verlag: De Gruyter
Format: PDF
Kopierschutz: 1 - PDF Watermark
Andreas Wagner is professor of biochemistry at the University of Zurich. He studies the evolution of biological systems on all levels of organismal organization, from genes and genomes to gene networks and embryonic development
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
List of Figures ix
Acknowledgments xiii
Chapter 1: Introduction 1
PART I: ROBUSTNESS BELOW THE GENE LEVEL 13
Chapter 2: The Genetic Alphabet 15
Chapter 3: The Genetic Code 25
Chapter 4: RNA Structure 39
Chapter 5: Proteins and Point Mutations 62
Chapter 6: Proteins and Recombination 78
PART II: ROBUSTNESS ABOVE THE GENE LEVEL 91
Chapter 7: Regulatory DNA Regions and Their Reorganization in Evolution 93
Chapter 8: Metabolic Pathways 104
Chapter 9: Metabolic Networks 120
Chapter 10: Drosophila Segmentation and Other Gene Regulatory Networks 143
Chapter 11: Phenotypic Traits, Cryptic Variation, and Human Diseases 161
Chapter 12: The Many Ways of Building the Same Body 175
PART III: COMMON PRINCIPLES 193
Chapter 13: Neutral Spaces 195
Chapter 14: Evolvability and Neutral Mutations 217
Chapter 15: Redundancy of Parts or Distributed Robustness? 228
Chapter 16: Robustness as an Evolved Adaptation to Mutations 247
Chapter 17: Robustness as an Evolved Adaptation to Environmental Change and Noise 270
Chapter 18: Robustness and Fragility: Advantages to Variation and Trade-offs 281
PART IV: ROBUSTNESS BEYOND THE ORGANISM 295
Chapter 19: Robustness in Natural Systems and Self-Organization 297
Chapter 20: Robustness in Man-made Systems 310
Epilogue: Seven Open Questions for Systems Biology 321
Bibliography 323
Index 359
