Vertebrate Carbonic Anhydrases

Erscheinungsjahr 2026
ISBN: 978-0-443-47086-8
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 450 g

Vertebrate Carbonic Anhydrases, Volume 59 in The Enzymes series, explores recent advances in the study of carbonic anhydrases (CAs) in vertebrate systems. This volume presents a comprehensive collection of chapters examining the diversity, structure, function, and physiological roles of vertebrate CA isoforms across multiple tissues and cellular compartments.

Chapters include discussions on the phylogenetic relationships of vertebrate carbonic anhydrases and detailed examinations of several important isoforms, including carbonic anhydrases I, II, and III, as well as membrane-associated enzymes such as CA IV and XV. Additional contributions explore mitochondrial carbonic anhydrases (CA VA and VB), secreted isoforms such as CA VI, and other cytosolic and membrane-associated enzymes including CA VII, CA XIII, and CA XIV.

The volume also examines acatalytic carbonic anhydrases and tumor-associated isoforms, providing insights into their structural characteristics and biological significance. A concluding chapter addresses current challenges and opportunities in the development of selective inhibitors and activators targeting vertebrate carbonic anhydrase isoforms, highlighting their potential therapeutic applications.

Together, these chapters offer an in-depth overview of vertebrate carbonic anhydrases, providing valuable insights for researchers in enzymology, biochemistry, molecular biology, and biomedical sciences.

Autoren/Hrsg.

Weitere Mitwirkende

Supuran, Claudiu T.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

1. Phylogenetic Relationship of Vertebrate Carbonic Anhydrases
2. Carbonic Anhydrases I and II
3. Carbonic Anhydrase III
4. Carbonic Anhydrases IV and XV
5. Mitochondrial Carbonic Anhydrases (CA VA/VB)
6. Carbonic Anhydrase VI
7. Carbonic Anhydrase VII
8. Acatalytic Carbonic Anhydrases (CA VIII, X and XII)
9. Carbonic Anhydrases IX and XII
10. Carbonic Anhydrase XIII
11. Carbonic Anhydrase XIV
12. Challenges and Opportunities for Developing Selective CA Inhibitors and Activators for Vertebrate Isoforms

Über Autor(innen)

Supuran, Claudiu T.
Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields.