van Leeuwen Science of Synthesis: C-1 Building Blocks in Organic Synthesis Vol. 2

Alkenations, Cross Couplings, Insertions, Substitutions, and Halomethylations
1. Auflage 2014
ISBN: 978-3-13-176551-2
Verlag: Thieme
Format: EPUB
Kopierschutz: Wasserzeichen (»Systemvoraussetzungen)

E-Book, Englisch, 558 Seiten, ePub, Format (B × H): 170 mm x 240 mm

The two-volume set on C-1 Building Blocks in Organic

Synthesis critically reviews the state of the art of a wide variety of reactions

by which one carbon atom is added to an organic molecule, forming a C-C bond. In

spite of the numerous classic reactions of this kind, there has been enormous

progress in recent years, especially for those reactions involving catalytic

methods. Introduction of substituted methyl groups is a major challenge and only

very recently the first catalysts have been discovered that enable the

introduction of fluoromethyl groups in aromatics.

Zielgruppe

Wissenschaftler

Autoren/Hrsg.

van Leeuwen, Piet W.N.M.

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie

Inhaltsverzeichnis

2.1 C-1 Alkenation
2.1.1 Modern Variants of Wittig, Peterson, and Tebbe Protocols
2.2 C—C Cross Coupling
2.2.1 Cross-Coupling Methods for Methylation
2.2.2 Carbonylation of Aryl and Vinyl Halides
2.2.3 Cyanation of Aryl Halides
2.2.4 Oxidative Coupling of Nitromethane
2.3 Insertion into C—H Bonds
2.3.1 Carbene Insertion into C—H Bonds with C-1
2.4 Insertion into C—O and C—N Bonds
2.4.1 Carbon Monoxide Insertion into Epoxides and Oxetanes
2.4.2 Carbon Monoxide Insertion into Aziridines
2.5 Substitution Reactions
2.5.1 Hydroformylation of Epoxides
2.5.2 Cyanation of Epoxides
2.5.3 Cyanation of Aziridines
2.5.4 Carboxylation of Organometallic Reagents
2.5.5 Reaction of Formaldehyde with Organometallic Reagents
2.5.6 Mannich-Type Reactions
2.5.7 Formylation and the Vilsmeier Reagent
2.5.8 Metathesis Adding a C-1 Unit
2.6 Halomethylation
2.6.1 Trifluoromethylation
2.6.2 Difluoro- and Fluoromethylation
2.6.3 Karasch Reaction (Atom-Transfer Radical Addition Reactions)