E-Book, Englisch, 480 Seiten
Tryphonas / Fournier / Blakley Investigative Immunotoxicology
Erscheinungsjahr 2005
ISBN: 978-1-4200-3681-7
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
E-Book, Englisch, 480 Seiten
ISBN: 978-1-4200-3681-7
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
Investigative Immunotoxicology provides a critical evaluation of proposed experimental animal models and approaches, and discusses the contribution that immunotoxicity can make to the overall assessment of chemical-induced adverse health effects on humans and the ecosystem. Following a review of general concepts in immunotoxicology, the book discusses emerging methodologies at the cellular and molecular levels, and describes advances in and requirements for animal model development in testing the allergenicity of foods and genetically modified products. It presents animal models of autoimmunity associated with chemical exposure, includes recommendations for the selection of sentinel species in ecotoxicology, and presents an in-depth review of immunotoxicology as it relates to a variety of wildlife species. Finally, the book explains the role of immunotoxicology in human health risk assessment and the regulatory process.
Outlining the potential chemical hazards facing human and ecosystem health, this is a valuable reference for professionals and researchers in immunotoxicology and risk assessment. It also deserves the attention of the pharmaceutical industry and environmental toxicologists who are concerned about the effects of xenobiotics on ecosystems.
Zielgruppe
Immunotoxicologists; environmental toxicologists and ecotoxicologists; risk assessment professionals, toxicologists and biologists
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
SECTION I. THE IMMUNE SYSTEM
Structural and Functional Complexity of the Immune System and its Relationship to Immunotoxicology, Barry R. Blakey and Edward Kouassi
SECTION II. APPROACHES AND MODELS RELEVANT TO THE ASSESSMENT OF CHEMICAL-INDUCED IMMUNOTOXIC EFFECTS IN THE ECOSYSTEM
Ecoimmunotoxicology: State of the Science, Michael R. Woolhiser, Kevin S. Henry, and Michael P. Holsapple
Bivalves as Models for Marine Immunotoxicology, Michael Auffrett
Approaches and Models for the Assessment of Chemical-Induced Immunotoxicity in Fish, Jessica E. Duffy and Judith T. Zelikoff
Immunotoxicology in Marine Mammals, Sylvain de Guise
Amphibian Models and Approaches to Immunotoxicology, Louise A. Rollins-Smith and Judit E.G. Smits
Earthworms as Ecosentinels for Chemical-Induced Immunotoxicology, Arthur J. Goven, Barney J. Venables, and Lloyd C. Fitzpatrick
Reptiles: The Research Potential of an Overlooked Taxon in Immunotoxicology, Andrew A. Rooney
Immunotoxicology in Terrestrial Wildlife, Judy Smits and David Janz
Immune Markers in Ecotoxicology: A Comparison Across Species, Harri Salo, Claire Dautremepuits, Judit Smis, Pauline Brousseau, and Michael Fournier
SECTION III: APPROACHES AND MODELS RELEVANT TO THE ASSESSMENT OF THE IMPACT OF CHEMICAL-INDUCED IMMUNOTOXICITY ON HUMAN HEALTH
Are Changes in the Immune System Predictive of Clinical Diseases?, Michael I. Luster, Dori R. Germolec, Christine G. Parks, Laura Blanciforti, Michael Kashon, and Robert Luebke
Developmental Immunotoxicology in Rodent Species, Barry R. Blakley and Patrcia M. Blakley
Gut Mucosal Immunotoxicology In Rodents, Genevieve S. Bondy and James J. Pestka
The Use of Old World Nonhuman Primates as Models for Evaluating Chemical-Induced Alterations of the Immune System, Helen Tryphonas and Douglas L. Arnold
Practical Considerations for Toxicologic Pathology Assessment of the Immune System in Rodents and Nonhuman Primates, Olga Pulido, Don Caldwell, Meghan Murphy, and Santokh Gill
Approaches to Immunotoxicology in Human Population Studies, Frédéric Dallaire, É ric Dewailly, and Pieree Ayotte
SECTION IV: MODELS AND APPROACHES TO CHEMMICAL-INDUCED ALLERGENICITY
Guinea Pig, Mouse, and Rat Models for the Safety Assessment of Protein Allergenicity, Katherine Sarlo, Rebecca J. Dearman, and Ian Kimber
Hypersensitivity Reactions: Nonrodent Animal Models, Ricki M. Helm
Recent Developments in Allergic Contact Dermatitis, Ian Kimber and Rebecca J. Dearman
Predictive Methods Specific for Human Immune Response, Fiona A. Harding, David Wong, and Donald P. Naki
SECTION V: AUTOIMMUNITY
Chemical-Induced Animal Models of Human Autoimmunity, Pierluigi E. Bigazzi
SECTION VI: EMERGING ISSUES IN IMMUNOTOXICOLOGY
Transgenic Rodent Mice in Immunotoxicology, Robert V. House
Applications of Genomics in Immunotoxicology, Sami Haddad, Michele D'Elia, Jacques Bernier, Alain Fournier, and Daniel G. Cyr
SECTION VII: THE ROLE OF IMMUNOTOXICOLOGY IN RISK ASSESSMENT AND THE REGULATORY PROCESS
Biomarkers of Immunotoxic Effects in the Context of Environmental Risk Assessment, Stépane Pillet and Jean-Marc Nicolas
Toxicological Considerations: Making the Connection Between Toxicologic and Immunotoxicologic Studies as These Relate to Human and Ecosystem Health, Michel Fournier, Barry R. Blakley, Herman J. Boermans, and Pauline Brousseau
Approaches to Immunotoxicity Testing: The Need for National and International Harmonization/Standardization of Immunotoxicity Methods, Pauline Brousseau, Barry R. Blakley, Herman J. Boermans, and Michel Fournier
Approaches to the Statistical Analysis of Immunotoxicologic Data in Support of Risk Assessment, Stephen Hayward
