Tofts Quantitative MRI of the Brain

Measuring Changes Caused by Disease
1. Auflage 2005
ISBN: 978-0-470-86949-9
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 650 Seiten, E-Book

2004 BMA Medical Book Competition Winner
(Radiology category)
"This is an exciting book, with a new approach to use ofthe MRI scanner. It bridges the gap between clinical research andgeneral neuro-radiological practice. It is accessible to theclinical radiologist, and yet thorough in its treatment of theunderlying physics and of the science of measurement. It is likelyto become a classic." British Medical Association
This indispensable 'how to' manual of quantitative MR isessential for anyone who wants to use the gamut of modernquantitative methods to measure the effects of neurologicaldisease, its progression, and its response to treatment. Itcontains both the methodology and clinical applications,reflecting the increasing interest in quantitative MR in studyingdisease and its progression.
* The editor is an MR scientist with an international reputationfor high quality research
* The contributions are written jointly by MR physicists and MRclinicians, producing a practical book for both the research andmedical communities
* A practical book for both the research and medicalcommunities
"Paul Tofts has succeeded brilliantly in capturing theessence of what needs to become the future of radiology inparticular, and medicine in general - quantitativemeasurements of disease." Robert I. Grossman, M.D. NewYork, University School of Medicine (from the Foreword)

Autoren/Hrsg.

Tofts, Paul

Inhaltsverzeichnis

Contributors.
Reviewers.
Foreward.
Introduction.
SECTION A: THE MEASUREMENT PROCESS.
1. Concepts: Measurement and MR (Paul S. Tofts).
2. The Measurement Process: MR Data Collection and ImageAnalysis (Paul S. Tofts).
3. QA: Quality Assurance, Accuracy, Precision and Phantoms (PaulS. Tofts).
SECTION B: WINDOWS INTO THE BRAIN; MEASURING MR PARAMETERS.
4. PD: Proton Density of Tissue Water (Paul Tofts).
5. T1: the Longitudinal Relaxation Time (Penny A.Gowland and Valerie L. Stevenson).
6. T2: the Transverse Relaxation Time (Philip A.Boulby and Fergus J. Rugg-Gunn).
7. D: the Diffusion of Water (Claudia A.M. Wheeler-Kingshott,Gareth J. Barker, Stefan C.A. Steens and Mark A. van Buchem).
8. MT: Magnetisation Transfer (Paul S. Tofts, Stefan C.A. Steensand Mark A. van Buchem).
9. Spectroscopy: ¯1H Metabolite Concentrations (PaulS. Tofts and Adam D. Waldman).
10. T1-w DCE-MRI:T1-weighted Dynamic Contrast-enhance d MRI (GeoffJ.M. Parker and Anwar Padhani).
11. T2- and T2*-w DCE-MRI:Blood Perfusion and Volume Estimation using Bolus Tracking (RichardP. Kennan and H. Rolf Ja¨ger).
12. Functional MRI (Peter Jezzard and Nick F. Ramsay).
13. ASL: Blood Perfusion Measurements using Arterial SpinLabelling (Laura M. Parkes, John A. Detre).
SECTION C: THE BIOLOGY.
14. Biology: The Significance of MR Parameters in MultipleSclerosis (Bruno Brochet, Klaus G. Petry and Vincent Dousset).
SECTION D: ANALYSING IMAGES.
15. Spatial Registration of Images (John Ashburner and CatrionaD. Good).
16. Volume and Atrophy (Geoff J.M. Parker and Declan T.Chard).
17. Shape and Texture (William R. Crum).
18. Histograms: Measuring Subtle Diffuse Disease (Paul S. Tofts,Gerard R. Davies and Jamshid Dehmeshki ).
SECTION E: WHERE ARE WE GOING?
19. The Future of qMRI: Conclusions and Speculation (Paul S.Tofts).
Appendix 1: Greek Alphabet for Scientific Use.
Index.

Über Autor(innen)

Professor Paul Tofts has worked on the physical aspects of quantitative brain imaging since the early days of clinical NMR. He was the first to measure in-vivo concentrations of metabolites, and to use dynamic imaging to measure blood-brain barrier permeability and extra-cellular space in multiple sclerosis.