Glycoscience

Synthesis of Substrate Analogs and Mimetics
1998
ISBN: 978-3-540-65546-6
Verlag: Springer Berlin Heidelberg

Buch, Englisch, 321 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 511 g

Reihe: Springer Desktop Editions in Chemistry

The synthesis of very complex saccharide structures is one of the most challenging areas of modern glycoscience. This volume presents the state of the art of complex carbohydrate synthesis, written by leading scientists whose groups are making major contributions in the field. Reflecting the particular interest in inhibitors and modulators as well as in mimetics, an in-cepth treatment is given both of their selective syntheses and of their biological implications. In addition the concept of multivalent glycoconjugate recognition as well as supramolecular implications of amphiphilic carbohydrates are highlighted.

Zielgruppe

Research

Autoren/Hrsg.

Thiem, Joachim

Driguez, Hugues

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

Nucleophilic C-glycosyl donors for C-glycoside synthesis.- Synthesis of C-glycosides of biological interest.- Thiooligosaccharides in glycobiology.- Aldonolactones as chiral synthons.- Chemical and chemo-enzymatic approaches to glycosidase inhibitors with basic nitrogen in the sugar ring.- The synthesis of novel enzyme inhibitors and their use in defining the active sites of glycan hydrolases.- Heparinoid mimetics.- Recent developments in the rational design of multivalent glycoconjugates.- Amphiphilk carbohydrates as a tool for molecular recognition in organized systems.