The Human Hypothalamus

Middle and Posterior Region Volume 180
Erscheinungsjahr 2021
ISBN: 978-0-12-820107-7
Verlag: Elsevier Science

Buch, Englisch, 548 Seiten, Format (B × H): 195 mm x 260 mm, Gewicht: 1440 g

The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the middle and posterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson's, Alzheimer's and other neurological disorders relate to the hypothalamus.

Zielgruppe

Clinical neurologists, researchers in neurology

Autoren/Hrsg.

Swaab, Dick F

Kreier, Felix

Lucassen, Paul J.

Salehi, Ahmad

Buijs, Ruud M.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Endokrinologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

1. Introduction: The middle and posterior hypothalamus

SECTION 6 Supraoptic and paraventricular nucleus more than a neuroendocrine system
2. Vasopressin and oxytocin beyond the pituitary in the human brain
3. Central and peripheral release of oxytocin: Relevance of neuroendocrine and neurotransmitter actions for physiology and behavior

4. Organization of the neuroendocrine and autonomic hypothalamic paraventricular nucleus

5. Sex differences of oxytocin and vasopressin in social behaviors

6. Oxytocin, eating behavior, and metabolism in humans

7. The supraoptic and paraventricular nuclei in healthy aging and neurodegeneration
8. Perinatal stress and epigenetics

9. The hypothalamus in anxiety disorders

10. Congenital isolated central hypothyroidism: Novel mutations and their functional implications

SECTION 7 Zona incerta
11. The zona incerta system: Involvement in attention and movement
SECTION 8 Ventromedial nucleus and dorsomedial nucleus
12. The role of the dorsomedial and ventromedial hypothalamus in regulating behaviorally coupled and resting autonomic drive

SECTION 9 Circumventricular organs of the hypothalamus
13. The subfornical organ and organum vasculosum of the lamina terminalis: Critical roles in cardiovascular regulation and the control of fluid balance

14. Lamina terminalis fenestration: An important neurosurgical corridor

15. Arcuate nucleus, median eminence, and hypophysial pars tuberalis
16. Tanycytes in the infundibular nucleus and median eminence and their role in the blood-brain barrier

17. The human hypothalamic kisspeptin system: Functional neuroanatomy and clinical perspectives

18. Kisspeptin and neurokinin B expression in the human hypothalamus: Relation to reproduction and gender identity

19. The infundibular peptidergic neurons and glia cells in overeating, obesity, and diabetes
20. Hypothalamus and weight loss in amyotrophic lateral sclerosis

SECTION 10 Lateral tuberal nucleus
SECTION 11 Lateral hypothalamic area, perifornical area
21. The orexin/hypocretin system in neuropsychiatric disorders: Relation to signs and symptoms

22. Pleasure, addiction, and hypocretin (orexin)

SECTION 12 Tuberomamillary complex
23. Histamine receptors, agonists, and antagonists in health and disease

24. The tuberomamillary nucleus in neuropsychiatric disorders
SECTION 13 Subthalamic nucleus
25. Imaging of the human subthalamic nucleus

26. Neuropsychiatric effects of subthalamic deep brain stimulation

27. The subthalamic nucleus and the placebo effect in Parkinson's disease

SECTION 14 Corpora mamillaria, fornix, and mamillothalamic tract
28. Electrical stimulation of the fornix for the treatment of brain diseases

29. The contribution of mamillary body damage to Wernicke's encephalopathy and Korsakoff's syndrome

Über Autor(innen)

Salehi, Ahmad
Ahmad Salehi is affiliated with Stanford Medical School, Department of Psychiatry & Behavioral Sciences, in Palo Alto, CA, United States.

Buijs, Ruud M.
Dr. Ruud M. Buijs is head of the Physiology department of the I.I.Biomedicas at the UNAM university and leader of the group Hypothalamic Integration Mechanisms. In that group, the scientists study how the brain and body interact with each other, and hereby the attention is focussed on autonomic and hormonal regulation of body functions under the influence of the biological clock of the brain.

Kreier, Felix
Felix Kreier is a pediatrician and affiliated with OLVG Hospitals in Amsterdam, The Netherlands.

Lucassen, Paul J.
Paul J. Lucassen did his PhD in 1995 on Alzheimer's Disease at the Netherlands Institute for Brain Research in Amsterdam.
After a.o. a postdoc in Leiden, he became Full Professor of Brain Plasticity in 2011 at the Swammerdam Institute for Life Sciences (SILS) of the University of Amsterdam, The Netherlands.
His group studies molecular, nutritional, pharmacological and environmental regulation of brain plasticity. They combine molecular tools, in vitro/vivo model systems, human brain tissue, cohort studies and brain imaging. A major focus is on adult neurogenesis and cognition in relation to; (early life) stress, exercise, enrichment, depression, brain insults and dementia.