Carbonic Anhydrases as Biocatalysts

Erscheinungsjahr 2015
ISBN: 978-0-444-63258-6
Verlag: Elsevier Science & Technology

Buch, Englisch, 398 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 896 g

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology.

Zielgruppe

<p>It can be useful for many type of readers: biochemists, chemists and specialists in drug design, but also medical doctors and for students of life sciences.</p>

Autoren/Hrsg.

Supuran, Claudiu T.

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

Preface

PART I INTRODUCTION 1. Carbonic Anhydrases: an overview

PART II CARBONIC ANHYDRASES AS DRUG TARGETS 2. Human Carbonic Anhydrases: catalytic properties, structural features and tissue distribution 3. Carbonic Anhydrase I 4. Carbonic Anhydrase II as target from drug design 5. Carbonic Anhydrase III 6. Carbonic Anhydrase IV 7. The structure, physiological role and potential medicinal applications of Carbonic Anhydrase V 8. Secreted Carbonic Anhydrase Isoenzyme VI 9. Carbonic Anhydrase VII 10. Tumor associated carbonic Anhydrases IX and XII 11. Carbonic anhydrase XIII 12. Carbonic anhydrase XIV: structure, functions and potential medical applications 13. Acatalytic Carbonic anhydrases (CAs VIII, X, XI) 14. Beta-class Carbonic anhydrases: general features and medical implications 15. Bacterial Carbonic Anhydrases as drug targets

PART III CARBONIC ANHYDRASES FOR BIOTECHNOLOGICAL APPLICATIONS 16. Engineered mammalian Carbonic Anhydrases for CO2 capture 17. Carbonic anhydrases from extremophiles and their biotechnological applications 18. Carbonic Anhydrases of environmentally and medically relevant anaerobic prokaryotes 19. Delta Carbonic anhydrases: structure, distribution and potential roles 20. CDCA1 from Thalassiosira weissflogii as representative member of zeta-class CAs: general features and biotechnological applications of anhydrases 21. Carbonic anhydrases as esterases and their biotechnological applications

Über Autor(innen)

Supuran, Claudiu T.
Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields.