Algorithms in Bioinformatics

A Practical Introduction
1. Auflage 2009
ISBN: 978-1-4200-7033-0
Verlag: Chapman and Hall/CRC

Buch, Englisch, 408 Seiten, Format (B × H): 161 mm x 240 mm, Gewicht: 775 g

Thoroughly Describes Biological Applications, Computational Problems, and Various Algorithmic Solutions

Developed from the author’s own teaching material, Algorithms in Bioinformatics: A Practical Introduction provides an in-depth introduction to the algorithmic techniques applied in bioinformatics. For each topic, the author clearly details the biological motivation and precisely defines the corresponding computational problems. He also includes detailed examples to illustrate each algorithm and end-of-chapter exercises for students to familiarize themselves with the topics. Supplementary material is available at http://www.comp.nus.edu.sg/~ksung/algo_in_bioinfo/

This classroom-tested textbook begins with basic molecular biology concepts. It then describes ways to measure sequence similarity, presents simple applications of the suffix tree, and discusses the problem of searching sequence databases. After introducing methods for aligning multiple biological sequences and genomes, the text explores applications of the phylogenetic tree, methods for comparing phylogenetic trees, the problem of genome rearrangement, and the problem of motif finding. It also covers methods for predicting the secondary structure of RNA and for reconstructing the peptide sequence using mass spectrometry. The final chapter examines the computational problem related to population genetics.

Zielgruppe

Undergraduate

Autoren/Hrsg.

Sung, Wing-Kin

Fachgebiete

• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Mathematik | Informatik EDV | Informatik Informatik
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)

Inhaltsverzeichnis

Introduction to Molecular Biology. Sequence Similarity. Suffix Tree. Database Search. Multiple Sequence Alignment. Genome Alignment. Phylogeny Reconstruction. Phylogeny Comparison. Genome Rearrangement. Motif Finding. RNA Secondary Structure Prediction. Peptide Sequencing. Population Genetics. References. Index.

Über Autor(innen)

Wing-Kin Sung is an associate professor at the National University of Singapore.