Mitochondria

The Dynamic Organelle
1. Auflage. Softcover version of original hardcover Auflage 2007
ISBN: 978-1-4419-2418-6
Verlag: Springer

Buch, Englisch, 359 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 563 g

Reihe: Advances in Biochemistry in Health and Disease

This book is indispensable to researchers in fields as diverse as molecular biology and biophysics. It is an essential text for university libraries, covering as it does the important role that mitochondria play in a variety of biochemical spheres. The work has been co-authored by two leading figures in the field of biomedical research. In it, they analyse how mitochondria affect metabolic pathways, how they are active in the regulation of cytosolic constituents, and their role in initiating signal pathways. Also covered are the way mitochondria help to regulate apoptosis, and how they modulate cellular hypertrophy and proliferation. It gives an overview of the emergence of mitochondria as an important regulator of cell signaling, with a particular focus on their pathophysiology.

Zielgruppe

Research

Autoren/Hrsg.

Suleiman, M. Saadeh

Schaffer, Stephen W.

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

Mitochondrial Metabolism.- Regulation of Mitochondrial Respiration in Heart Muscle.- Regulation of Fatty Acid Oxidation of the Heart.- Regulation of Mitochondrial Fuel Handling by the Peroxisome Proliferator-Activated Receptors.- Molecular Structure of the Mitochondrial Citrate Transport Protein.- Regulation of Pyruvate and Amino Acid Metabolism.- Amino Acids and the Mitochondria.- The Dynamic Nature of the Mitochondria.- Mechanotransduction of Shear-stress at the Mitochondria.- Mitochondria as Initiators of Cell Signaling.- Formation of Reactive Oxygen Species in Mitochondria.- Mitochondrial Calcium: Role in the Normal and Ischaemic/Reperfused Myocardium.- Mitochondrial Ion Channels.- Mitochondria as Initiators of Cell Death.- The Mitochondrial Permeability Transition Pore – from Molecular Mechanism to Reperfusion Injury and Cardioprotection.- The Apoptotic Mitochondrial Pathway – Modulators, Interventions and Clinical Implications.- The Role of Mitochondria in Necrosis Following Myocardial Ischemia-Reperfusion.- Mitochondria as Modulators of Cell Death.- Mitochondria and Their Role in Ischemia/Reperfusion Injury.- Mitochondrial DNA Damage and Repair.

Über Autor(innen)

Dr. Stephen W. Schaffer is a professor at the University of South Alabama. He is a member of the editorial board of Molecular and Cellular Biochemistry.

Dr. M.-Saadeh Suleiman is a professor at the University of Bristol, UK. His research includes investigating the role of metabolites and ionic species in myocardial protection, with special emphasis on amino acids, mitochondria, Ca2+ loading and reactive oxygen species.