Striessnig Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease

1. Auflage 2023
ISBN: 978-3-031-38437-0
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 279, 316 Seiten, eBook

Reihe: Handbook of Experimental Pharmacology

The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.

Zielgruppe

Research

Autoren/Hrsg.

Striessnig, Jörg

Inhaltsverzeichnis

Preface.- Part 1 Modulation.-   Cav1.1Calcium Channel Signaling Complexes in Excitation–Contraction Coupling: Insights from Channelopathies.- Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia.- Sympathetic Nervous System Regulation of Cardiac Calcium Channels.- Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19.-  Part 2 Pharmacological Approaches.-  Pathophysiological Roles of Auxiliary Calcium Channel a2d Subunits.- Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors.-  Part 3 Disease insight from channelopathies: consequences for pharmacology and therapeutic strategies.-     CACNA1C-Related Channelopathies.- CACNA1D-Related Channelopathies: From Hypertension to Autism.- CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options.- CaV3.2 (CACNA1H) in Primary Aldosteronism,- CaV3.3 Channelopathies.- Pathophysiological Roles of Auxiliary Calcium Channel a2d Subunits.