Theory and Practice
Buch, Englisch, 273 Seiten, Format (B × H): 157 mm x 235 mm, Gewicht: 1350 g
ISBN: 978-0-306-46595-6
Verlag: Springer US
Scientists from many disciplines require making observations which are dependent upon the behavior of compounds in solution. This ranges from areas in geography, such as oceanography, to areas in chemistry, such as chromatography, to areas in biology, such as pharmacology. Historically, information would be obtained by observing a response for a given set of conditions and then the conditions would be changed and a new response obtained. In this approach there would be little effort made to actually understand how a compound was behaving in solution but rather just the response was noted. Understanding the behavior of compounds in solution is critical to understanding their behavior in biological systems. This has become increasingly important during the last twenty years as an understanding of the biochemistry related to human illness has become better understood. The development of the pharmaceutical industry and the need to rapidly screen large numbers of compounds has made scientists in the area of drug development aware that the pharmacological activity of compounds can be predicted by knowing their solution physical chemical properties. This is not to say that a specific drug-active site interaction can be predicted but rather a prediction can be made whether or not a compound will be absorbed, transported, or distributed within a physiological system in such a way that an interaction can occur.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Chemie Organische Chemie
- Naturwissenschaften Chemie Analytische Chemie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
- Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Kosmetische Technologie
- Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
- Naturwissenschaften Chemie Physikalische Chemie
Weitere Infos & Material
Compound Characterization.- Thermodynamics.- Kinetics.- Equilibrium Constants.- Partition Coefficient.- Solubility.- Aqueous Solubility of Weak Acids and Bases.- Solution Stability.- Instrumentation.- Equilibria: Experimental Procedures and Examples.- Partitioning: Experimental Procedures and Examples.- Solubility: Experimental Procedures and Examples.- Solution Kinetics: Experimental Procedures and Examples.
