Astrocytes

Wiring the Brain
2. Auflage 2025
ISBN: 978-1-032-75616-5
Verlag: Taylor & Francis Ltd

Buch, Englisch, 376 Seiten, Format (B × H): 178 mm x 254 mm, Gewicht: 453 g

Reihe: Frontiers in Neuroscience

This is a second edition of a book that provides an overview of the most current findings on the diverse roles played by astrocyte in CNS function and dysfunction with emphasis on its cellular connections.

Astrocytes are highly elaborated cells and likely the only neural cells that simultaneously establish associations with different cellular types. The fine processes of astrocytes are found nearby practically all cellular types in the central nervous system (CNS), including astrocytes themselves, neurons, oligodendrocytes, and brain endothelial cells. Such close morphological associations, together with the fact that astrocytes express a multitude of ion channels, transporters and membrane receptors, endows these cells with the unique capability to sense and influence diverse CNS functions.

Disruption of these elaborated connections and altered astrocyte polarization are implicated in numerous pathological conditions such as epilepsy, stroke, leukodystrophies, Alzheimer and Autism, and also certain psychiatric disorders, major depression and schizophrenia.

Zielgruppe

Academic, Postgraduate, and Professional Reference

Autoren/Hrsg.

Spray, David C.

Scemes, Eliana

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Biowissenschaften
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

1. What is an astrocyte: Diversity of structures and functions. 2. Gap junctions and Aquaporins. 3. Adhesion molecules in astrocytes. 4. Multi scale astrocyte-neuron communication. 5. Blood-Brain-Barrier and the Neural-Vascular Unit. 6. Oligodendrocytes: Gateway to the panglial syncytium. 7. Critical role of astrocytes in the development of epilepsy. 8. The Role of Glial Pathology in Autism Spectrum Disorders. 9. Astrocytes in Aging and Alzheimer’s Disease. 10. Astrocytes in Stroke. 11. Astrocytes in Depression: insights from postmortem human studies and animal models.

Über Autor(innen)

Dr. Eliana Scemes is a Professor at New York Medical College. She obtained her PhD degree in General Physiology from the University of Sao Paulo, Brazil and obtained further postdoctoral training in Neurobiology in Brazil and in Neuroscience at Albert Einstein College of Medicine. Dr. Scemes research has made significant contributions to the understanding of astrocyte biology, focusing on gap junction proteins (connexins and pannexins) and their impact on CNS physiopathology. She has contributed over 100 publications, h-index of 49, in the form of research and review articles and book chapters and has been a member of numerous professional Societies and Editorial Board Member of many Scientific Journals.

David C. Spray is a Professor in the Dominick P Purpura Department of Neuroscience and Department of Medicine at Albert Einstein College of Medicine and Adjunct Professor of Biomedical Engineering at the City College of New York. His Ph.D. in Physiology at the University of Florida College of Medicine, supported by one of the first Centers for Neuroscience, dealt with transduction properties of peripheral sensory neurons. As a Grass Foundation Fellow and for more than a dozen years afterward, he spent summers doing research at the Marine Biological Laboratory in Woods Hole MA. His primary research focus has been on gap junctions, where current research of the laboratory focuses on neuron-glial interactions in peripheral ganglia associated with several models of chronic pain, and gap junction control of the blood-brain-barrier at the astrocyte end feet. Dr Spray has published about 500 papers, h-index >100, and with Dr Scemes has co-authored more than 50 original articles and reviews, primarily dealing with gap junctions and astrocytes. He has served on NIH Study Sections, including Molecular Biology of Glia, which he chaired, and is on the editorial boards of numerous journals, including Glia.