Coagulation and Blood Transfusion

Proceedings of the Fifteenth Annual Symposium on Blood Transfusion, Groningen 1990, organized by the Red Cross Blood Bank Groningen-Drenthe
1991
ISBN: 978-0-7923-1331-1
Verlag: Springer US

Buch, Englisch, Band 26, 270 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 1290 g

Reihe: Developments in Hematology and Immunology

With great pleasure I welcome you to the City of Groningen. In more than one way there is cause for celebration. Today marks the third lustrum of the annual international sympo­ sium on blood transfusion, organized by the Rode Kruis Bloedbank Groningen-Drenthe. In my opinion it has been a remarkable initiative of the Bloedbank, to start organizing a scientific conference, as it did, in 1976. It meant, among others, that in case of success the initiative would grow to be an annual item on the international congress calen­ der. It also meant that a possible third lustrum would coincide with the celebration of the 950th anniversary of the City of Groningen. I am happy to note that the initiative has been successful: over the past fourteen years the Rode Kruis Bloedbank Groningen-Drenthe has succeeded in organizing an annual symposium on blood transfusion, with a different theme each year, and with an average attendance of 250 participants from some 26 countries world-wide. The platform created with the special formula of the symposium, for science and industry, has been well balanced and beneficial to both. Mr. Chairman, ladies and gentlemen, I like to compliment the organizers with the success that they have attained. Allow me to men­ tion the name of just one person, in whom I like to thank everyone who has been involved in creating the annual Bloedbank-symposia: my warm congratulations to Dr. Smit Sibinga and his staff.

Zielgruppe

Research

Autoren/Hrsg.

Smit Sibinga, C. Th.

Mannucci, P. M.

Das, P.C.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Hämatologie, Transfusionsmedizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

I. Principles and fundamentals.- The mechanisms of thrombin formation.- Structure-function relationships of human coagulation proteins.- The role of calcium in coagulation and anticoagulation.- Effect of blood collection on the hemostatic potential of coagulation proteins.- Factor VIII yields from anticoagulant exchanged Haemonetics Ultralite™ plasma.- Discussion.- II.Preservation aspects.- Platelet function preservation.- Platelet adhesion to the vessel wall.- Trends in the production and use of coagulation factor concentrates.- Immunoaffinity purification of Factor VIII/von Willebrand factor complex.- Structural and functional properties of recombinant coagulation factors.- Discussion.- III. Laboratory Aspects.- Platelet counting and function testing.- Selection of platelet apheresis donors for alloimmunized patients by ELISA platelet crossmatch versus HLA-matching.- Clinical efficacy of platelet concentrates.- Principles of coagulation factor assays.- Standardization of clotting factor assays.- Protein C and S in swiss blood donors.- Clinical efficacy of clotting factor concentrates: survival, recovery and hemostatic capacity.- Discussion.- IV. Clinical consequences.- Principles in the treatment of bleeding.- The effect of chronic exposure to clotting factor concentrates on the immune system.- Liver transplantation and blood usage.- The use of aprotinin in cardiopulmonary bypass and the impact on hemostasis and blood transfusion.- Discussion.