Innovative Targeting Strategies in Breast Cancer Therapy

Erscheinungsjahr 2025
ISBN: 978-0-443-33349-1
Verlag: Elsevier Science

Buch, Englisch, 320 Seiten, Format (B × H): 191 mm x 235 mm

Innovative Targeting Strategies in Breast Cancer Therapy is a comprehensive reference addressing the challenge of non-specific drug distribution in the body, along with severe toxicity and adverse effects, by offering insights into targeted breast cancer treatment. It further educates researchers on formulating and developing novel carriers with target-specific attributes (such as targeted liposomes, nanoparticles, micelles, and dendrimers), contributing to a more refined approach to breast cancer. This book's content is presented in 12 chapters. The first chapters introduces the reader to the different breast cancer therapies followed by indepth information on targeting. Recognizing the need for targeted drug delivery in breast cancer treatment, this book presents an encompassing compilation of advanced research and formulation strategies. By focusing on effectively targeting cancer cells, the book mitigates dose-related toxicity associated with cytotoxic drugs, providing a comprehensive resource for improved treatment approaches. Research in oncology, pharmacology, medical researchers, biomedical engineers and clinical professionals will find this an essential reference.

Autoren/Hrsg.

Singh, Pankaj Kumar

Chourasia, Manish K

Dua, Kamal

Guru, Santosh Kumar

Singh, Sachin Kumar

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

1. Chemotherapeutic drugs and its side effects, breast cancer biomarkers, detection, level of targeting and EPR effect
2. Receptor-ligand based targeting approaches breast cancer
3. Stimuli-based targeting breast cancer
4. Advance strategies for targeting severe triple-negative breast cancer
5. Targeted therapy for BRCA gene mutations breast cancer
6. Androgen receptor targeted therapy for breast cancer
7. Monoclonal antibodies-based breast cancer targeting
8. Breast cancer stem cell targeting
9. The Role of Hormone Receptors in Breast Cancer: New opportunities for Treatment and Prevention
10. HER2-positive and HER2-negative Targeted Therapies
11. Immunotherapy for breast cancer
12. Current market formulation, therapy in clinical trails, and status of IPR for breast cancer

Über Autor(innen)

Guru, Santosh Kumar
Dr. Kumar Guru is currently at NIPER in Hyderabad. He holds a PhD in pharmaceutical science.His research group mainly focus on basic and applied drug discovery in cancer biology and on role of drug tolerant persistent cell and chemotherapy induced tumor dormancy in cancer. He explores the survival mechanism of these dormant tumors through Autophagy, epigenetic, RNA methylation, efferocytosis, ferroptosis, EMT and YAP/TAZ mechanism.

Chourasia, Manish K
Dr. Manish K. Chourasia, is currently working as a Senior Principal Scientist in the Division of Pharmaceutics and Pharmacokinetics at CSIR-Central Drug Research Institute (CDRI), Lucknow, a premium drug research institute in India. He received his PhD in Pharmaceutical Sciences from Dr. Harisingh Gour University, Madhya Pradesh, India and carried out his post-doctoral studies at Department of Pharmacy, National University of Singapore, Singapore. Having acquired valuable experience in both industry and academia, he subsequently joined the role of a scientist at CSIR-CDRI almost two decades ago. He has played a significant role in advancing the field of nanoparticle-based drug delivery for breast cancer, aiming to enhance the therapeutic outcome. He has published 80+ scientific papers including high-impact journal reviews. He has supervised more than 50 MS students and PhD students.

Singh, Pankaj Kumar
Dr. Pankaj Kumar Singh, Ph.D., is an Assistant Professor in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education and Research-Hyderabad (NIPER-Hyderabad), India. He earned his Doctorate in Pharmaceutics from CSIR-Central Drug Research Institute, Lucknow. Dr. Singh is actively involved in various scientific and socially impactful projects funded by prestigious organizations, including TSCOST-DBT, CCRUM, DST, ICMR, and the Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India.