The Secret Lives of Transcription Factors

In Heterochromatin Regulation
1. Auflage 2023
ISBN: 978-3-031-29027-5
Verlag: Springer International Publishing

Buch, Englisch, 45 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 113 g

Reihe: SpringerBriefs in Biochemistry and Molecular Biology

This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.

Zielgruppe

Research

Autoren/Hrsg.

Silver-Morse, Louise

Li, Willis X.

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik

Inhaltsverzeichnis

Chapter 1 Introduction.- Chapter 2 Unconventional functions of transcription factors.- GAGA transcription factor.- Heterochromatin protein 1.- Retinoblastoma protein.- STAT.- ATF-2.- NF-kB.- Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer.- STAT and HP1 promote longevity.- STAT and HP1 protect against DNA damage.- Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model.- Chapter 4 The possible biological significance of transcription factors’ unconventional functions.- The epigenome.- Processes in the cell nucleus.- Future Work.

Über Autor(innen)

Dr. Willis X. Li received his Ph.D. from Columbia University and is currently Professor of Medicine in the Biomedical Sciences Graduate Program at the University of California, San Diego. He is a prolific author and his more recent works include two books for Springer's Methods in Molecular Biology/Protocols series. His investigative interests are JAK/STAT signaling and innate immunity, epigenetic mechanism of tumor suppression and tumorigenesis, and the role of heterochromatin in aging and stem cells.

Dr. Louis Silver-Morse received her Ph.D. from the State University of New York at Stony Brook.  She did research in genetics as a postdoctoral fellow in the Department of Biomedical Genetics at the University of Rochester Medical Center.  She has published research articles and reviews in premier scientific journals.  She is currently a freelance writer/editor.