E-Book, Englisch, 588 Seiten
Reihe: ISSN
Sigel / Freisinger Metallo-Drugs: Development and Action of Anticancer Agents
1. Auflage 2018
ISBN: 978-3-11-046990-5
Verlag: De Gruyter
Format: EPUB
Kopierschutz: 6 - ePub Watermark
Development and Action of Anticancer Agents
E-Book, Englisch, 588 Seiten
Reihe: ISSN
ISBN: 978-3-11-046990-5
Verlag: De Gruyter
Format: EPUB
Kopierschutz: 6 - ePub Watermark
Volume 18, entitled of the series centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of -diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.
Zielgruppe
Scientists in biochemistry, inorganic chemistry, medicine, pharma
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Chemie Anorganische Chemie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
- Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
- Naturwissenschaften Biowissenschaften Molekularbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
Weitere Infos & Material
From the Content: - Introduction to the Wider Field of Metallo-Drugs
- Cisplatin and Oxaliplatin: Our Current Understanding of Their Actions
- Polynuclear Platinum Drugs: Covalent and Non-covalent DNA-Binding Agents
- Different Drugs, Different Actions: The Actions and Consequences of Trans and Cationic Platinum Drugs
- Platinum(IV) Drugs
- The Ruthenium Drugs KP1019 and NAMI-A: Our Current Understanding of Their Actions
- Ruthenium Piano-Stool Organometallic Drugs
- The Gold Drugs
- Titanium Drugs
- Vanadium Drugs
- Non-covalent Metallo-Drugs: Targeting Junction Structures
- Metallo-Drugs that Target Proteins
- Non-canonical Nucleic Acid Targets: Metallo-Drugs that Act on Quadruplexes
- Targeting, Delivery and Nanoscience of Metallo-Drugs
- Metallo-Intercalators
