Sigalov Multichain Immune Recognition Receptor Signaling

From Spatiotemporal Organization to Human Disease
1. Auflage 2008
ISBN: 978-0-387-09789-3
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 640, 357 Seiten

Reihe: Advances in Experimental Medicine and Biology

This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.

ALEXANDER SIGALOV, PhD, is a Research Assistant Professor in the Department of Pathology at the University of Massachusetts Medical School in Worcester, Massachusetts, USA. His main research interests include protein intrinsic disorder and oligomericity in the context of transmembrane signal transduction, the molecular mechanisms underlying immune receptor-mediated signaling and ways to control these processes and thus to modulate the immune response, as well as the development and applications of novel targets and strategies for innovative immune therapy. He discovered and investigated a very unusual and unique biophysical phenomenon, the homooligomerization of intrinsically disordered proteins, thus providing the first evidence for the existence of specific interactions between unfolded protein molecules. In the field of immunology, he unraveled a long-standing mystery of transmembrane signaling and immune cell activation triggered by multichain immune recognition receptors. Later, he developed a novel concept of platelet inhibition and invented a novel class of platelet inhibitors. In the field of immune therapy, he proposed new therapeutic strategies for a variety of malignancies and immune disorders, including immunodeficiencies, inflammatory and autoimmune diseases, allergy and HIV. He is a member of the American Association for the Advancement of Science and the Biophysical Society, USA. Alexander Sigalov received his academic degrees (MSc in Chemistry and a PhD in Organic Chemistry) from Moscow State University, Russia.

Autoren/Hrsg.

Sigalov, Alexander

Inhaltsverzeichnis

1;DEDICATION;6
2;FOREWORD;7
3;PREFACE;9
4;ABOUT THE EDITOR...;11
5;PARTICIPANTS;12
6;CONTENTS;17
7;ACKNOWLEDGEMENTS;24
8;T- Cell Receptor;25
9;B- Cell Receptor;36
10;Fc Receptors;46
11;Natural Killer Cell Receptors;59
12;Platelet Glycoprotein VI;77
13;Clustering Models;88
14;Segregation Models;98
15;Kinetic Proofreading Model;106
16;Serial Triggering Model;119
17;Conformational Model;127
18;Permissive Geometry Model;137
19;Signaling Chain Homooligomerization ( SCHOOL) Model;145
20;Visualization of Cell- Cell Interaction Contacts— Synapses and Kinapses;188
21;Visualization of Protein Interactions in Living Cells;207
22;Immunogenicity in Peptide- Immunotherapy;222
23;Therapeutic Application of Transmembrane T and Natural Killer Cell Receptor Peptides;232
24;Fc Receptor Targeting in the Treatment of Allergy, Autoimmune Diseases and Cancer;244
25;Therapeutic Blockade of T- Cell Antigen Receptor Signal Transduction and Costimulation in Autoimmune Disease;258
26;MHC and MHC- Like Molecules;276
27;SCHOOL Model and New Targeting Strategies;292
28;Immune Receptor Signaling, Aging and Autoimmunity;336
29;Viral Pathogenesis, Modulation of Immune Receptor Signaling and Treatment;349
30;INDEX;374