Shankel / Hartman / Kada Antimutagenesis and Anticarcinogenesis Mechanisms

1986
ISBN: 978-1-4684-5182-5
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 39, 618 Seiten, eBook

Reihe: Basic Life Sciences

Zielgruppe

Research

Autoren/Hrsg.

Shankel, Delbert M.

Hartman, Philip E.

Kada, Tsuneo

Hollaender, Alexander

Wilson, Claire M.

Kuny, Gregory

Inhaltsverzeichnis

Keynote Address.- Carcinogens and Anticarcinogens.- Activation and Inactivation of Mutagens and Carcinogens– –Part I.- The Relation of Activation and Inactivation to Antimutagenic Processes.- Cancer and Free Radicals.- Cytochromes P-450 and the Activation and Inactivation of Mutagens and Carcinogens.- Alteration of Mutagenic Potentials by Peroxidase, Catalase, and Superoxide Dismutase.- Activation and Inactivation of Mutagens and Carcinogens– –Part II.- Effects of Vitamins C and E on Carcinogen Formation and Action, and Relationship to Human Cancer.- Modifiers of Endogenous Nitrosamine Synthesis and Metabolism.- Glutathione Transferases and Carcinogenesis.- Natural Environmental Antimutagens.- Introduction: Natural Environmental Antimutagens.- Antioxidants/Antimutagens in Foods.- Role of Enzymes in Antimutagenes is of Human Saliva and Serum.- Isolation and Identification of Higher Plant Agents Active in Antimutagenic Assay Systems: Glycyrrhiza glabra.- Mechanism of Action of Antimutagens and Anticarcinogens.- Interception of Toxic Agents/Mutagens/Carcinogens: Some of Nature’s Novel Strategies.- Antimutagens and Their Modes of Action.- Avoidance of Errors in Dna.- Introduction: Avoidance of Spontaneously Occurring Errors in DNA.- Introduction: Avoidance of Errors After DNA Damage.- Alkylation and Oxidative Damages to DNA: Constitutive and Inducible Repair Systems.- Molecular Mechanism of Adaptive Response to Alkylating Agents.- Nucleotide Excision Repair Genes from the Yeast Saccharomyces cerevisiae.- The Fixation of Errors.- Introduction: Molecular Basis of Genomic Stability and Change.- Genetic Analyses of the Roles of UmuDC and MucAB in Mutagenesis.- Mechanisms of Spontaneous Mutagenesis: Clues from Altered Mutational Specificity in DNA Repair-DefectiveStrains.- Genetics and Molecular Biology of Mammalian Cells– –Part I.- Introduction: Comparative Responses to DNA Damage in Bacteria and Mammalian Cells.- Inducible Cellular Responses to DNA Damage in Mammalian Cells.- Single-Base Mutations Associated with Mouse Lymphomas.- The Mouse Mutant “Wasted”: An Animal Model for Ataxia-Telangiectasia.- Genetics and Molecular Biology of Mammalian Cells– –Part II.- Introduction: Oxygen Metabolism, DNA Repair, and the Origin of Spontaneous Genetic Instability.- Multiple Inducible Cytochromes P-450 in Yeast.- DNA Repair Genes of Mammalian Cells.- Genetic and Chemical Factors Affecting Chemical Mutagenesis in Cultured Mammalian Cells.- Mechanisms of Carcinogenicity and Anticarcinogenicity––Part I.- Mechanisms of Carcinogenicity and Anticarcinogenicity: Role of Dietary Components.- Reducing the Genotoxic Damage in the Oral Mucosa of Betel Quid/Tobacco Chewers.- The Concentration of Bile Acids in the Fecal Stream as a Risk Factor for Colon Cancer.- Hormones and Dietary Factors Controlling Gene Activation and Expression in Carcinogenesis.- Dietary Promoters and Antipromoters.- Mechanisms of Carcinogenicity and Anticarcinogenicity– –Part II.- A Mutagen Is a Mutagen, Not Necessarily a Carcinogen.- DNA Repair and Replication in Xeroderma Pigmentosum and Related Disorders.- Role of Intercellular Communication in Modifying the Consequences of Mutations in Somatic Cells.- Mechanisms of Carcinogenicity and Anticarcinogenicity– –Part III.- Genetic Aspects of Cancer Epidemiology.- Protective Effects of Beta-Carotene Against Psoralen Phototoxicity: Relevance to Protection Against Carcinogenesis.- Anticarcinogenic and Other Protective Effects of Dithiolthiones.- Antioxidants as Antitumor Promoters.- Future Directions forResearch in Antimutagenesis and Anticarcinogenesis.- Introduction: Future Directions for Research in Antimutagenesis and Anticarcinogenesis.- Inhibitors of Mutagenesis and Their Relevance to Carcinogenesis.- Population Consequences of Mutagenesis and Antimutagenesis.- A Summary––And a Look Ahead.- Poster Abstracts.- Organizing Committee.