Senn Cross-over Trials in Clinical Research

2. Auflage 2003
ISBN: 978-0-470-85458-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 364 Seiten, E-Book

Reihe: Statistics in Practice

Cross-over trials are an important class of design used in thepharmaceutical industry and medical research, and their usecontinues to grow. Cross-over Trials in Clinical Research, SecondEdition has been fully updated to include the latest methodologyused in the design and analysis of cross-over trials. It includesmore background material, greater coverage of important statisticaltechniques, including Bayesian methods, and discussion of analysisusing a number of statistical software packages.
* Comprehensive coverage of the design and analysis of cross-overtrials.
* Each technique is carefully explained and the mathematics is keptto a minimum.
* Features many real and original examples, taken from the author'svast experience.
* Includes discussion of analysis using SAS, S-Plus and, GenStat,StatXact and Excel.
* Written in a style suitable for statisticians and physiciansalike.
* Computer programs to accompany the examples in the book can bedownloaded from the Web
Primarily aimed at statisticians and researchers working in thepharmaceutical industry, the book will also appeal to physiciansinvolved in clinical research and students of medicalstatistics.

Autoren/Hrsg.

Senn, Stephen S

Inhaltsverzeichnis

Preface to the Second Edition.
Preface to the First Edition.
1. Introduction.
2. Some Basic Considerations Concerning Estimation in ClinicalTrials.
3. The AB/BA Design with Normal Data.
4. Other Outcomes and the AB/BA Design.
5. Normal Data from Designs with Three or More Treatments.
6. Other Outcomes from Designs with Three or More Treatments.
7. Some Special Designs.
8. Graphical and Tabular Presentation of Cross-over Trials.
9. Various Design Issues.
10. Mathematical Approaches to Carry-over.
References.
Author Index.
Subject Index.