Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries

1. Auflage 2001
ISBN: 978-0-471-37828-0
Verlag: Wiley

Buch, Englisch, 320 Seiten, Format (B × H): 162 mm x 237 mm, Gewicht: 576 g

In jüngster Zeit hat sich die Palette der Festphasenreaktionen um neue Methoden zur Kohlenhydratsynthese erweitert. Dieses Buch beschreibt Details der Fixierung von Kohlenhydraten an gekörnten Trägern, u.a. Kopplung und Screening sowie Strategien zur Herauslösung des Reaktionsprodukts. Mit Beiträgen führender Kohlenhydratchemiker!

Autoren/Hrsg.

Seeberger, Peter H

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Chemie Organische Chemie Supramolekularchemie

Inhaltsverzeichnis

Preface.

Contributors.

Solid-Phase Carbohydrate Synthesis: The Early Work (W.-C. Haase & P. Seeberger).

The Glycal Assembly Method on Solid Supports: Synthesis of Oligosaccharides and Glycoconjugates (P. Cirillo & S. Danishefsky).

The Sulfoxide Glycosylation Method and its Application to Solid-Phase Oligosaccharide Synthesis and the Generation of Combinatorial Libraries (C. Taylor).

The Use of O-Glycosyl Trichloroacetimidates for the Polymer-Supported Synthesis of Oligosaccharides (L. Knerr & R. Schmidt).

Synthesis of Oligosaccharides on Solid Support Using Thioglycosides and Pentenyl Glycosides (V. Wittmann).

Solid-Phase Oligosaccharide Synthesis Using Glycosyl Phosphates (W.-C. Haase, et al.).

Stereoselective -Mannosylation on Polymer Support (Y. Ito & H. Ando).

Tools for "On-Bead" Monitoring and Analysis in Solid-Phase Oligosaccharide Synthesis (W.-C. Haase, et al.).

Polyethyleneglycol -Monomethylether (MPEG)-Supported Solution-Phase Synthesis of Oligosaccharides (J. Krepinsky & S. Douglas).

Two-Direction Glycosylations for the Preparation of Libraries of Oligosaccharides (G.-J. Boons & T. Zhu).

Carbohydrate Libraries in Solution Using Thioglycosides: From Multistep Synthesis to Programmable, One-Pot Synthesis (E. Simanek & C.-H. Wong).

Carbohydrate Libraries by the Random Glycosylation Approach (O. Kanie & O. Hindsgaul).

Solid-Phase Synthesis of Biologically Important Glycopeptides (N. Bézay & H. Kunz).

Preparation and Screening of Glycopeptide Libraries (P. St. Hilaire, et al.).

Index.

Über Autor(innen)

PETER H. SEEBERGER is Firmenich Assistant Professor of Chemistry at the Massachusetts Institute of Technology in Cambridge, Massachusetts.