Scott Linker Strategies in Solid-Phase Organic Synthesis

1. Auflage 2009
ISBN: 978-0-470-74905-0
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 706 Seiten, E-Book

Linker design is an expanding field with an exciting future instate-of-the-art organic synthesis. Ever-increasing numbers ofambitious solution phase reactions are being adapted forsolid-phase organic chemistry and to accommodate them, largenumbers of sophisticated linker units have been developed and arenow routinely employed in solid-phase synthesis.
Linker Strategies in Solid-Phase Organic Synthesis guidesthe reader through the evolution of linker units from their genesisin solid-supported peptide chemistry to the cutting edge diversitylinker units that are defining a new era of solid phasesynthesis. Individual linker classes are covered in easy tofollow chapters written by international experts in theirrespective fields and offer a comprehensive guide to linkertechnology whilst simultaneously serving as a handbook of synthetictransformations now possible on solid supports. Topics include:
* the principles of solid phase organic synthesis
* electrophile and nucleophile cleavable linker units
* cyclative cleavage as a solid phase strategy
* photocleavable linker units
* safety-catch linker units
* enzyme cleavable linker units
* T1 and T2 -versatile triazene linker groups
* hydrazone linker units
* benzotriazole linker units
* phosphorus linker units
* sulfur linker units
* selenium and tellurium linker units
* sulfur, oxygen and selenium linker units cleaved by radicalprocesses
* silicon and germanium linker units
* boron and stannane linker units
* bismuth linker units
* transition metal carbonyl linker units
* linkers releasing olefins or cycloolefins by ring-closingmetathesis
* fluorous linker units
* solid-phase radiochemistry
The book concludes with extensive linker selection tables,cataloguing the linker units described in this book according tothe substrate liberated upon cleavage and conditions used toachieve such cleavage, enabling readers to choose the right linkerunit for their synthesis.
Linker Strategies in Solid-Phase Organic Synthesis is anessential guide to the diversity of linker units for organicchemists in academia and industry working in the broad areas ofsolid-phase organic synthesis and diversity oriented synthesis,medicinal chemists in the pharmaceutical industry who routinelyemploy solid-phase chemistry in the drug discovery business, andadvanced undergraduates, postgraduates, and organic chemists withan interest in leading-edge developments in their field.

Autoren/Hrsg.

Scott, Peter