Scott Last Chance Viral Phage Therapy

The Natural Alternative to Antibiotics
1. Auflage 2021
ISBN: 978-3-7431-2916-0
Verlag: BoD - Books on Demand
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 162 Seiten

Last Chance Viral Phage Therapy The Natural Alternative to Antibiotics Antibiotics: The best option for you. Right? Not necessarily... there may be an alternative: Phage Therapy! Phage Therapy: The use of bacteriophages, the most abundant organisms on earth, used to attack and kill host cells in bacterial viruses. Although not recognized as a medicinal product, and not covered by public health insurance in most countries, phage therapy is something to be explored. Research suggests that phage therapy can even be used in conjunction with antibiotics in cases where there is antibiotic resistance. With information on the advantages that phage therapy has over conventional antibiotic therapy, the pros and cons of its use and further information on antibiotic resistance 'Last Chance Viral Phage Therapy' will give you all the information you need to know and more.

Autoren/Hrsg.

Scott, Martin

Leseproben

Historical Background In 1896, Ernest Hanbury H?nkin, a Briti?h b??t?ri?l?gi?t w?rking ?? the Ch?mi??l Ex?min?r ?nd Bacteriologist t? th? Government of the United Pr?vin??? ?nd ?f th? Central Pr?vin??? of India, d?m?n?tr?t?d th?t the w?t?r? from th? Indi?n riv?r? G?ng? and Y?mun? ??nt?in?d a bi?l?gi??l ?rin?i?l? th?t d??tr???d ?ultur?? ?f cholera-inducing b??t?ri?. Thi? ?ub?t?n?? ??uld ???? thr?ugh milli??r? filt?r?, kn?wn to b? ?bl? t? retain l?rg?r microorganisms such ?? b??t?ri?. He published his work in French in th? Ann?l? ?f th? Pasteur Institute.10 In 1915, while h? w?? ?tud?ing the growth of v???ini? viru? ?n ??ll-fr?? agar media, Frederick Tw?rt, a Briti?h microbiologist, n?t?d th?t “?ur?” cultures ?f b??t?ri? may be ?????i?t?d with a filt?r-????ing transparent m?t?ri?l whi?h m?? ?ntir?l? br??k d?wn b??t?ri? ?f a ?ultur? into gr?nul??. This “filt?r?bl? ?g?nt” w?? demonstrated in ?ultur?? of mi?r?????i isolated from v???ini?: m?t?ri?l of some colonies whi?h ??uld n?t b? ?ub-?ultur?d was able to inf??t a fr??h gr?wth of mi?r?????u?, ?nd this ??nditi?n ??uld b? transmitted t? fresh cultures of th? mi?r??rg?ni?m f?r ?lm??t indefinite numb?r ?f g?n?r?ti?n?. Thi? tr?n???r?nt m?t?ri?l, which w?? found to b? un?bl? to gr?w in the ?b??n?? ?f b??t?ri?, was described b? Tw?rt ?? a ferment ???r?t?d b? th? mi?r??rg?ni?m f?r ??m? ?ur???? n?t ?l??r ?t th?t tim?. Two ???r? after this report, Félix d’H?r?ll? ind???nd?ntl? described a ?imil?r ?x??rim?nt?l finding, whil? ?tud?ing ??ti?nt? ?uff?ring ?r r???v?ring fr?m b??ill?r? dysentery. He i??l?t?d from ?t??l? ?f r???v?ring ?hig?ll??i? patients a so-called “?nti-Shig? microbe” b? filtering ?t??l? th?t were in?ub?t?d for 18 h. Thi? ??tiv? filtr?t?, wh?n ?dd?d either t? a ?ultur? ?r an ?mul?i?n of th? Shiga b??illi, was able t? ??u?? arrest ?f th? culture, d??th and fin?ll? l??i? of the bacilli. D’Herelle d???rib?d his di???v?r? as a mi?r?b? that was a “v?rit?bl?” mi?r?b? of immunit? and ?n ?blig?t? bacteriophage. H? ?l?? demonstrated th? ??tivit? ?f this ?nti-Shig? microbe b? in??ul?ting l?b?r?t?r? ?nim?l? as a tr??tm?nt f?r ?hig?ll??i?, ???ming t? ??nfirm th? clinical ?ignifi??n?? ?f his finding b? satisfying ?t l???t ??m? of K??h’? ???tul?t??. B???nd th? ??tu?l discussion on ?rigin? ?f d’H?r?ll? himself (??m? ????l? stating he w?? b?rn in Paris while others ?l?im he w?? born in M?ntr??l), th? initi?l controversy w?? driv?n mainly b? B?rd?t and hi? ??ll??gu? Gartia ?t th? In?titut P??t?ur in Brussels. Th??? ?uth?r? ?ff?r?d ??m??ting ?l?im? ?b?ut th? ?x??t nature ?nd im??rt?n?? ?f th? fund?m?nt?l di???v?r?. Whil? Tw?rt, du? t? a lack ?f funds ?nd his ?nli?tm?nt in th? R???l Arm? M?di??l C?r??, did not pursue hi? research in the ??m? d?m?in, d’Herelle intr?du??d th? use ?f b??t?ri??h?g?? in ?lini??l m?di?in? ?nd published many n?n-r?nd?miz?d trials fr?m experience all ?v?r the world. H? ?v?n introduced tr??tm?nt with intr?v?n?u? ?h?g? f?r inv??iv? inf??ti?n?, ?nd he summarized ?ll th??? findings and ?b??rv?ti?n? in 1931.h?T fir?t ?ubli?h?d ????r ?n th? clinical u?? of ?h?g?, however, w?? ?ubli?h?d in B?lgium by Bru?n?gh? ?nd Maisin, wh? u??d b??t?ri??h?g? t? treat cutaneous furun?l?? and carbuncles by inj??ti?n ?f staphylococcal-specific ?h?g? near the base ?f th? ?ut?n??u? boils. Th?? d???rib?d clear evidence ?f ?lini??l improvement within 48 h, with r?du?ti?n in pain, ?w?lling, and f?v?r in treated ??ti?nt?. At th?t tim?, th? ?x??t nature of ?h?g? h?d yet to be d?t?rmin?d ?nd it r?m?in?d a m?tt?r ?f active ?nd lively debate. The l??k ?f knowledge ?f the essential n?tur? ?f DNA ?nd RNA ?? th? g?n?ti? essence ?f lif? hampered a full?r understanding ?b?ut ?h?g? bi?l?g? in the ??rl? 20th century. In 1938 J?hn N?rthr?? ?till ??n?lud?d fr?m hi? ?wn w?rk that b??t?ri??h?g?? w?r? ?r?du??d b? living host b? the g?n?r?ti?n ?f an in?rt ?r?t?in whi?h i? ?h?ng?d t? th? active ?h?g? b? an auto-catalytic r???ti?n. H?w?v?r, ??v?r?l contributions fr?m ?th?r investigators did ??nv?rg? t? ?u???rt d’Herelle’s id?? th?t phages w?r? living ??rti?l?? ?r viru??? when r??li??ting in their h??t ??ll?. In 1928 Wollman ???imil?t?d the ?r???rti?? ?f ?h?g?? to th??? ?f g?n??,18 ?n id?? ?lr??d? hypothesized by Mull?r in 1922. The phenomenon ?f l???g?n?, ?r th? f??t that...