Molecular Imaging II

1. Auflage. Softcover version of original hardcover Auflage 2008
ISBN: 978-3-642-09609-9
Verlag: Springer

Buch, Englisch, Band 185/2, 365 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 598 g

Reihe: Handbook of Experimental Pharmacology

The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is beeing addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.

Zielgruppe

Research

Autoren/Hrsg.

Schwaiger, Markus

Semmler, Wolfhard

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Amplification Strategies.- Optical Methods.- PET and SPECT.- Environment-sensitive and Enzyme-sensitive MR Contrast Agents.- Molecular Targets and Biomarkers for Imaging.- Peptides, Multimers and Polymers.- Small Molecule Receptors as Imaging Targets.- Enzymes/Transporters.- Phage Peptide Display.- Applications: Experimental Imaging.- Molecular Imaging: Reporter Gene Imaging.- The Use of Ultrasound in Transfection and Transgene Expression.- Magnetic Resonance of Mouse Models of Cardiac Disease.- Translational Imaging: Imaging of Apoptosis.- Molecular Imaging of PET Reporter Gene Expression.- Noninvasive Cell Tracking.- Noninvasive Tracer Techniques to Characterize Angiogenesis.- Molecular Imaging-guided Gene Therapy of Gliomas.