Scherer Batch Effects and Noise in Microarray Experiments

Sources and Solutions
1. Auflage 2009
ISBN: 978-0-470-68599-0
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 272 Seiten, E-Book

Reihe: Wiley Series in Probability and Statistics

Batch Effects and Noise in Microarray Experiments: Sources andSolutions looks at the issue of technical noise and batcheffects in microarray studies and illustrates how to alleviate suchfactors whilst interpreting the relevant biological information.
Each chapter focuses on sources of noise and batch effectsbefore starting an experiment, with examples of statistical methodsfor detecting, measuring, and managing batch effects within andacross datasets provided online. Throughout the book the importanceof standardization and the value of standard operating proceduresin the development of genomics biomarkers is emphasized.
Key Features:
* A thorough introduction to Batch Effects and Noise inMicrorarray Experiments.
* A unique compilation of review and research articles onhandling of batch effects and technical and biological noise inmicroarray data.
* An extensive overview of current standardizationinitiatives.
* All datasets and methods used in the chapters, as well ascolour images, are available on www.the-batch-effect-book.org,so that the data can be reproduced.
An exciting compilation of state-of-the-art review chapters andlatest research results, which will benefit all those involved inthe planning, execution, and analysis of gene expressionstudies.

Autoren/Hrsg.

Scherer, Andreas

Über Autor(innen)

Andreas Scherer studied biology in Cologne, Germany, andFreiburg, Germany, and received his Ph.D. for his studies in thefields of genetics, developmental biology, and microbiology.Following a postdoctoral position at UT Southwestern Medical Centerin Dallas, TX, he worked for many years in pharmaceutical industryin various positions in the field of experimental and statisticalgenomics biomarker discovery. In 2007, Andreas Scherer foundedSpheromics, a company specialized in analytical and consultancyservices in gene expression technologies and biomarkerdevelopment.