New Enzymes for Organic Synthesis

Screening, Supply and Engineering
1. Auflage 1997. 2. printing 1999
ISBN: 978-3-540-65549-7
Verlag: Springer Berlin Heidelberg

Buch, Englisch, 237 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 382 g

Reihe: Springer Desktop Editions in Chemistry

Isolated enzymes are known as useful for synthesising of complex molecules with more and more large scale applications in recent years. These six reviews show different steps in the development of enzymatic syntheses for useful compounds. Screening of novel enzymes, their biochemical characterisation as well as reaction engineering approaches in order to increase their performance are treated in three papers. Then the use of protein design as a tool for the directed improvement of reactivity and selectivity of biocatalysts is described in two reviews. The supply of sufficient quantities of biocatalysts must not be neglected: fluidized bed adsorption as an emerging technology for the simple and fast purification of biomolecules is presented in the light of its potential in large scale supply of enzyme catalysts.

Zielgruppe

Research

Autoren/Hrsg.

Scheper, Thomas

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Chemie Organische Chemie Supramolekularchemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Industrielle Biotechnologie

Inhaltsverzeichnis

Optimizing industrial enzymes by directed evolution.- Protein design on pyruvate decarboxylase (PDC) by site-directed mutagenesis.- Screening of novel microbial enzymes for the production of biologically and chemically useful compounds.- Glycobiotechnology: Enzymes for the synthesis of nucleotide sugars.- New alcohol dehydrogenases for the synthesis of chiral compounds.- Fluidized bed adsorption as a primary recovery step in protein purification.