Schenkman / Greim Cytochrome P450

Erscheinungsjahr 2013
ISBN: 978-3-642-77763-9
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 105, 739 Seiten, eBook

Reihe: Handbook of Experimental Pharmacology

In this book the editors have brought together the widest group of investigators of the cytochrome P450 superfamily in order to present complete and right up-to-date coverage of this important enzyme system. The authors describe and analyze the components of the enzyme system, the reaction mechanisms involved, and the evolution and nomenclature of this superfamily of enzymes. They also describe the hepatic microsomal enzyme in a large number of species, from mammalian to birds and fish, to plants and unicellular organisms. The different P450 forms in different tissues of the mammalian system are also treated. Regulatory factors of P450 expression receive considerable attention, as do studies on the mechanism of interaction of the microsomal monooxygenase system components. Of particular interest to the reader are, for the first time, a compilation of chapters dedicated to forms of cytochrome P450 involved in steroid hormone biosynthesis. This volume presents the most complete survey of the cytochrome P450 field. It will allow recognition and understanding of the very wide implications this enzyme system has on life processes.

Zielgruppe

Research

Autoren/Hrsg.

Schenkman, John B.

Greim, Helmut

Weitere Mitwirkende

Arinc, E.

Backes, W.L.

Benveniste, I.

Bernard, Roger

Birnbaum, L.S.

Black, S.D.

Blanck, J.

Bresnick, E.

Coon, M.J.

Corbin, C.J.

Curnow, K.M.

Daly, A.K.

Ding, X.

Doehmer, J.

Durst, F.

Fasco, M.J.

Feyereisen, R.

Fujii-Kuriyama, Y.

Funae, Y.

Gonzales, F.J.

Graham-Lorence, S.E.

Gray, R.W.

Greim, H.

Guengerich, F.P.

Gustafsson, J.-A.

Hammond, D.K.

Hollis, B.W.

Idle, J.R.

Imaoka, S.

Jansson, I.

Jung, C.

Käppeli, O.

Kaminsky, L.S.

Kappus, H.

Kasper, C.B.

Kato, R.

Kilgore, M.W.

Kühn-Velten, W.N.

Levin, W.

Mahendroo, M.S.

Marletta, M.A.

Means, G.D.

Mendelson, C.R.

Müller-Enoch, D.

Noshiro, M.

Obach, R.S.

Ogishima, T.

Okuda, K.

Omura, T.

Ortiz de Montellano, P.R.

Pascoe, L.

Rein, H.

Ruckpaul, K.

Ryan, D.E.

Sanglard, D.

Schenkman, J.B.

Schwarz, L.R.

Shen, A.L.

Simpson, E.R.

Sinclair, J.F.

Sinclair, P.R.

Sogawa, K.

Stegeman, J.J.

Stralka, D.J.

Strobel, H.W.

Strobl, G.

Vickery, L.E.

Warner, M.

Waxman, D.J.

White, K.A.

White, P.C.

White, T.

Wiebel, F.J.

Wikvall, K.

Wolff, T.

Yamazoe, Y.

Yoshida, Y.

Zimniak, P.

Inhaltsverzeichnis

Section I: The Monooxygenase System.- 1 Historical Background and Description of the Cytochrome P450 Monooxygenase System.- 2 NADPH-Cytochrome P450 Reductase: Function.- 3 Protein and Gene Structure and Regulation of NADPH-Cytochrome P450 Oxidoreductase.- 4 Localization of Cytochrome P450 in Membranes: Mitochondria.- 5 Localization of Cytochrome P450 in Membranes: Reconstituted Systems.- Section II: The Monooxygenase Reactions.- 6 Metabolic Reactions: Types of Reactions of Cytochrome P450 Enzymes.- 7 Metabolic Reactions: Mechanisms of Substrate Oxygenation.- 8 Liver Cytochrome P450 Metabolism of Endogenous Steroid Hormones, Bile Acids, and Fatty Acids.- 9 Metabolic Reactions: Role of Cytochrome P450 in the Formation of Reactive Oxygen Species.- 10 Cytochrome P450 Structure and Function.- 11 Structure of Cytochrome P450: Heme-Binding Site and Heme Reactivity.- 12 Cytochrome P450: Probes of Active Site Residues.- 13 Structural Models for Substrates and Inhibitors of Cytochrome P450 Enzymes.- Section III: Forms of Microsomal P.- 14 Cytochrome P450 Evolution and Nomenclature.- 15 Cytochrome P450 in Rodents.- 16 Cytochrome P450 in Humans.- 17 Avian Cytochrome P450.- 18 Cytochrome P450 Forms in Fish.- 19 Cytochrome P450 in Plants.- 20 Cytochrome P450 in Insects.- 21 Cytochrome P450 in Unicellular Organisms.- 22 Extrahepatic Microsomal Forms: Olfactory Cytochrome P450.- 23 Extrahepatic Microsomal Forms: Gastrointestinal Cytochromes P450, Assessment and Evaluation.- 24 Extrahepatic Microsomal Forms: Lung Microsomal Cytochrome P450 Isozymes.- 25 Extrahepatic Microsomal Forms: Brain Cytochrome P450.- 26 Cytochrome P450 in Primary and Permanent Liver Cell Cultures.- 27 Cytochromes P450 in Genetically Engineered Cell Cultures: The Gene Technological Approach.- Section IV: Modulation of Cytochrome P450 Levels.- 28 Genetics: Animal and Human Cytochrome P450 Polymorphisms.- 29 Hormonal Regulation of Cytochrome P450 in Rat Liver.- 30 Age- and Gender-Related Expression of Rat Liver Cytochrome P450.- 31 Changes in Cytochrome P450 in Senescence.- 32 Regulation of Cytochrome P450 Expression.- 33 Induction of Cytochromes P450 1 and P450 2 by Xenobiotics.- Section V: Chemical Modification, Protein-Protein and Protein-Lipid Interaction.- 34 Protein-Protein Interactions.- 35 Chemical Probes of Cytochrome P450 Structure.- 36 Posttranslational Modification of Cytochrome P450.- 37 Lipid-Protein Interactions.- Section VI: Biosynthetic Forms of Cytochrome P.- 38 Cholesterol 7?-Hydroxylase and 12?-Hydroxylase.- 39 Tissue-Specific Regulation of Aromatase Cytochrome P450 (CYP19) Expression.- 40 Lanosterol 14a-Demethylase (Cytochrome P45014DM).- 41 Steroid 11ß-Hydroxylase Isozymes (CYP11B1 and CYP11B2).- 42 Cholesterol Side Chain Cleavage Cytochrome P450 (P450scc).- 43 Cytochrome P450cl7: Regulation of Gene Expression and Enzyme Function at the Bifurcation in Steroid Hormone Synthesis.- 44 25-Hydroxy vitamin D-la-Hydroxylases: An Examination of Renal and Extrarenal Sources.- 45 Steroid 21-Hydroxylase.- 46 Sterol 26-Hydroxylase.- 47 Nitric Oxide Synthase (NOS).