Modulation of Oxidative Stress

Biochemical, Physiological and Pharmacological Aspects
Erscheinungsjahr 2023
ISBN: 978-0-443-19247-0
Verlag: Elsevier Science

Buch, Englisch, 306 Seiten, Format (B × H): 216 mm x 276 mm, Gewicht: 840 g

Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer's disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids.

This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out.

Autoren/Hrsg.

Saso, Luciano

Giuffre, Alessandro

Valacchi, Giuseppe

Maccarrone, Mauro

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

1. Antioxidants as modulators of the Ubiquitin-proteasome system against aging and proteinopathies
2. Modulation of oxidative stress by S-nitrosation and other thiol modifications
3. Regulation of Nrf2 Signaling Pathway and the Hallmarks of Aging: An Overview
4. Fluid redox biomarkers in neurological disease
5. CCM proteins are key players in redox signaling and oxidative stress regulation in Cerebral
6. Effects of maternal and early life nutrition on redox homeostasis
7. Mitochondria-associated membranes (MAMs) as modulators of oxidative stress in Alzheimer's disease
8. Oxidative stress biomarkers in human health and disease
9. Modulation of the antioxidant defense system against pathophysiological redox imbalance in cardiovascular diseases
10. Modulation of cancer cell proliferation by interfering with metabolic ROS production
11. Modulation of human hydrogen sulfide metabolism by physiological effectors
12. Intestinal redox and Inflammatory Bowel Disease
13. Applications of Plant-Derived Products in Photodynamic Therapy
14. Hopes and disappointments related to the use of flavonoids in therapeutical approaches
15. Omega-3 nutritional intervention as therapeutic coadjuvant approach to improve Rett Syndrome clinical and biochemical features
16. A glance on antioxidants: the role of sulfur amino acids in retinal disorders
17. Oxidative stress and antioxidant-based therapies in couple infertility
18. Modulation of oxidative stress in psoriasis: Pathophysiology and therapy

Über Autor(innen)

Saso, Luciano
Prof. Luciano Saso is a Professor of Pharmacology of the Faculty of Pharmacy and Medicine of Sapienza University of Rome, Italy. He is author of more than 350 original scientific articles published in peer reviewed international journals mainly in the field of pharmacological modulation of oxidative stress (H-index Google Scholar 62). He coordinated several international research projects and has been referee for many national and international funding agencies and international scientific journals in the last 25 years and he has been Editor and Guest Editor of Special Issues of different international journals.

Valacchi, Giuseppe
Dr. Valacchi has been interested in evaluating the effect of exogenous and endogenous sources of oxidative stress on target organs, such as skin, GI tract and lung, and the signal pathways involved in the cellular responses to these insults with special focus on epithelial wound healing. In addition, he aims to study how new topical approaches (derived from natural and synthetic compounds) can ameliorate wound healing and tissue regeneration in both physiological and pathological situations. In the last 10 years he has also been pursuing research involved in understanding the role of oxidative stress in a rare disease, Rett Syndrome, defined as a neurodevelopment pathology, and in the aging processes and how dietary intervention can improve the clinical feature.

Giuffre, Alessandro
Prof. Alessandro Giuffrè is a Senior Researcher of the National Research Council of Italy (Consiglio Nazionale delle Ricerche - CNR). Since 2020 he is Director of the CNR Institute of Molecular Biology and Pathology (IBPM) in Rome. Since he was awarded his PhD in Biochemistry in 1997, he has investigated the molecular mechanisms underlying the metabolism of O2, nitric oxide (NO), hydrogen sulfide (H2S) and related reactive species, with the ultimate goal of elucidating the role of these molecules in human physiology and pathophysiology. His research has focused on a variety of microbial and human enzymes and their ability to metabolize O2, NO and related species, as well as on the effects of NO on cellular bioenergetics. More recently his interests have extended also to H2S, another important small gaseous molecule with a key role in cell signaling. Currently, he has signed 95 articles in peer-reviewed International journals, with more than 3.500 citations.