Buch, Englisch, 448 Seiten, Format (B × H): 207 mm x 404 mm, Gewicht: 765 g
Buch, Englisch, 448 Seiten, Format (B × H): 207 mm x 404 mm, Gewicht: 765 g
ISBN: 978-1-119-89622-7
Verlag: Wiley
Impact of Engineered Nanomaterials in Genomics and Epigenomics
Overview of current research and technologies in nanomaterial science as applied to omics science at the single cell level
Impact of Engineered Nanomaterials in Genomics and Epigenomics is a comprehensive and authoritative compilation of the genetic processes and instructions that specifically direct individual genes to turn on or off, focusing on the developing technologies of engineering nanomaterials and their role in cell engineering which have become important research tools for pharmaceutical, biological, medical, and toxicological studies.
Combining state-of-the art information on the impact of engineered nanomaterials in genomics and epigenomics, from a range of internationally recognized investigators from around the world, this edited volume offers unique insights into the current trends and future directions of research in this scientific field.
Impact of Engineered Nanomaterials in Genomics and Epigenomics includes detailed information on sample topics such as: - Impact of engineered nanomaterials in genomics and epigenomics, including adverse impact on glucose energy metabolism
- Toxicogenomics, toxicoepigenomics, genotoxicity and epigenotoxicity, and mechanisms of toxicogenomics and toxicoepigenomics
- Adverse effects of engineered nanomaterials on human environment and metabolomics pathways leading to ecological toxicity
- Meta-analysis methods to identify genomic toxicity mechanisms of engineered nanomaterials and biological effects of engineered nanomaterial exposure
- Artificial intelligence and machine learning of single-cell transcriptomics of engineered nanoparticles and trends in plant nano-interaction to mitigate abiotic stresses
This comprehensive work is a valuable and excellent source of authoritative and up-to-date information for advanced students and researchers, toxicologists, the drug industry, risk assessors and regulators in academia, industry, and government, as well as for clinical scientists working in hospital and clinical environments.
Autoren/Hrsg.
Fachgebiete
- Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
- Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
- Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
- Technische Wissenschaften Technik Allgemein Nanotechnologie
Weitere Infos & Material
Contents
List of Contributors xv
Preface xix
Acknowledgments xxi
1 Impact of Engineered Nanomaterials in Genomics and Epigenomics 1
Saura C. Sahu Contents
Nanotechnology: A Technological Advancement of the Twenty-First Century 1
Genomics and Epigenomics 1
Beneficial Impacts of Engineered Nanomaterials on Human Life 2
Potential Adverse Health Effects of Engineered Nanomaterials 2
Conclusions 3
References 3
2 Molecular Impacts of Advanced Nanomaterials at Genomic and Epigenomic Levels 5
Kamran Shekh, Rais A Ansari, Yadollah Omidi, and Saghir A. Shakil
Introduction 5
Classification of NMs 6
Absorption and Distribution of NMs 6
Major Adverse Effects of NMs 8
Known Cellular and Nuclear Uptake Mechanisms for Nanoparticles 10
Epigenetic Mechanisms and the Effect of NMs 11
DNA Methylation 12
Genetic and Genomic Effects of NMs 20
Conclusion 25
References 26
3 Endocrine Disruptors: Genetic, Epigenetic, and Related Pathways 41
Rais A. Ansari, Saleh Alfuraih, Kamran Shekh, Yadollah Omidi, Saleem Javed, and Saghir A. Shakil
Introduction 41
Toxic Effects of EDCs on Wildlife and Humans 47
Effects During Development 48
Delayed Effects 48
Transgenerational Effects 49
Identification of EDC: Methods 49
Genetic Pathways 50
Phosphorylation-Mediated Signaling Pathways of Nuclear Receptors and Other Transcription Factors: Link to EDC 53
ER-Signaling Pathways 53
Xenoandrogens and Metabolic Syndrome 54
AR Signaling Pathways 54
Mechanism of ED 55
Methylation and Gene Regulation 55
Role of Noncoding RNAs 59
Transgenerational Inheritance of Epigenetics Induced by EDCs 59
Anti-Thyroids 60
Organotin 62
Epigenetic Effects of Organotin 63
TCDD and Related Compounds 63
TCDD and Genetic Response 64
TCDD-Mediated Epigenetic Response 65
Conclusions 65
References 66
4 Nanoplastics in Agroecosystem and Phytotoxicity: An Evaluation of Cytogenotoxicity and Epigenetic Regulation 83
Piyoosh Kumar Babele and Ravi Kant Bhatia
Introduction 83
Fate and Behavior of NPs in Agroecosystem and Soil Environment 85
Uptake and Accumulation of NPs in Plants 87
NPs and Phytotoxicity 88
Can NPs Cause Cytogenotoxicity and Dysregulate Epigenetic Markers in Plants? 89
NPs and Epigenetic Regulation 91
Conclusion and Perspectives 92
References 93
5 Metal Oxide Nanoparticles and Graphene-Based Nanomaterials: Genotoxic, Oxidative, and Epigenetic Effects 99
Delia Cavallo, Pieranna Chiarella, Anna Maria Fresegna, Aureliano Ciervo, Valentina Del Frate, and Cinzia Lucia Ursini
Introduction 99
Physicochemical Properties of NMs and Toxicity 100
Mechanism of NM Genotoxicity 101
Epigenetic Effects of Nanomaterials 102
Studies on Genotoxic and Oxidative Effects of Metal Oxides and Graphene-Based Nanomaterials 104
Graphene-Based NMs 120
Studies on Epigenetic Effects of Metal Oxides and Graphene-Based Nanomaterials 123
Studies on Workers – Genotoxic and Oxidative Effects of Occupational Exposure to Metal Oxides Nanoparticles, SiO2 NPs, and Graphene-Based Nanomaterials 127
Conclusions 132
References 132
6 Epigenotoxicity of Titanium Dioxide Nanoparticles 145
Carlos Wells, Marta Pogribna, Beverly Lyn-Cook, and George Hammons
Introduction 145
Cellular Uptake and Biodistribution 147
DNA Methylation and TiO2 Nanoparticles 151
Histone Modifications and TiO2 Nanoparticles 157
MicroRNAs and TiO2 Nanoparticles 161
Risk Assessment 167
Conclusion 173
Disclaimer 174
References 174
7 Toxicogenomics of Multi-Walled Carbon Nanotubes 187
Pius Joseph
Introduction 187
MWCNTs 188
Lung Injury 190
Inflammation 190
