Buch, Englisch, 197 Seiten, Format (B × H): 157 mm x 235 mm, Gewicht: 504 g
Reihe: Medical Intelligence Unit
Buch, Englisch, 197 Seiten, Format (B × H): 157 mm x 235 mm, Gewicht: 504 g
Reihe: Medical Intelligence Unit
ISBN: 978-0-387-25562-0
Verlag: Springer US
Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment.
This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy.
This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
- Naturwissenschaften Biowissenschaften Molekularbiologie
- Naturwissenschaften Biowissenschaften Zellbiologie
- Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
- Sozialwissenschaften Psychologie Allgemeine Psychologie Biologische Psychologie, Neuropsychologie
Weitere Infos & Material
History and Morphology of the Lysosome.- Transport of Lysosomal Enzymes.- Adaptor Proteins in Lysosomal Biogenesis.- Lysosomal Membrane Proteins.- Lysosomal Proteases.- Lysosomal Storage Disorders.- Lysosomal Transporters and Associated Diseases.- Neuronal Ceroid-Lipofuscinoses.- Cholesterol Transport in Lysosomes.- Therapy of Lysosomal Storage Diseases.- Lysosomal Proteome and Transcriptome.- External Lysosomes.- Membrane Resealing Mediated by Lysosomal Exocytosis.- Macroautophagy in Mammalian Cells.- Chaperone-Mediated Autophagy.
