Rupp Biomolecular Crystallography

Principles, Practice, and Application to Structural Biology
1. Auflage 2009
ISBN: 978-1-134-06419-9
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 800 Seiten

Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Deftly illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. It distills key concepts for understanding the practice and analysis of protein crystal structures and contains examples of biologically-relevant molecules, complexes, and drug target structures.
Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.

Autoren/Hrsg.

Rupp, Bernhard

Fachgebiete

• Technische Wissenschaften Umwelttechnik | Umwelttechnologie Umwelttechnik
• Geowissenschaften Umweltwissenschaften Umwelttechnik

Inhaltsverzeichnis

PART I: FROM SEQUENCE TO CRYSTALS
1. Introduction: Preparing Your Study
2. Protein Structure
3. Protein Crystallization
4. Proteins for Crystallography

PART II: FUNDAMENTALS OF PROTEIN CRYSTALLOGRAPHY
5. Crystal Geometry
6. Diffraction Basics
7. Statistics and Probability in Crystallography

PART III: FROM CRYSTALS TO DATA
8. Instrumentation and Data Collection

PART IV: DETERMINING YOUR STRUCTURE
9. Reconstruction of Electron Density and the Phase Problem
10. Experimental Phasing
11. Non-Crystallographic Symmetry and Molecular Replacement
12. Model Building and Refinement

PART V: MAKING SENSE OF YOUR STRUCTURE
13. Structure Validation, Analysis, and Presentation