E-Book, Englisch, Band 364, 324 Seiten
Rummel / Binz Botulinum Neurotoxins
1. Auflage 2012
ISBN: 978-3-642-33570-9
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, Band 364, 324 Seiten
Reihe: Current Topics in Microbiology and Immunology
ISBN: 978-3-642-33570-9
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark
The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.
